UPGRADING THE RESEARCH ANIMAL FACILITY

升级研究动物设施

• 批准号: 3451044
• 负责人: RICHARD R FOX
• 金额: $ 16.33万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-08-01 至 1989-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3451044
• 关键词: animal care; animal colony; athymic mouse; building /facility design /renovation; veterinary medicine

The Jackson Laboratory is a private not-for-profit research organization incorporated under the laws of the state of Maine since 1929. The work of the Laboratory spans three overlapping areas: research, resource and training. The Research Animal Facility benefits all of these areas by providing high quality animal care and competent technical assistance to investigators, trainees and resource personnel. Laboratory Animal Medicine programs provide comprehensive veterinary, diagnostic and monitoring activities. In addition, Genetic Quality Control monitors the genetic integrity of Jackson Laboratory mice. The aim of this proposal is to upgrade the Research Animal Facility by the addition of 22 units of pressurized, individually ventilated (PIV) caging - complete with polycarbonate cages, stainless steel covers, bottles and filter/blower modules - and 4 mobile HEPA filtered change stations. These units are required by investigators who are using immunodeficient mice in their research programs. These heritable immunological defects in mice are excellent models for immunodeficiency and autoimmunity disease in man, but research is often hampered by the fact that these animals are susceptible to infection by opportunistic microorganisms, even when housed under the exceptionally clean conditions prevailing in the Research Animal Facility. In order to collect accurate data and generate reproducible results, these investigators must be confident that the immunological responses under investigation are not the result of opportunistic infection. The addition of PIV caging will address this problem and help achieve the goal of the Research Animal Facility to provide all investigators with the highest quality animal care possible.

杰克逊实验室是一个私人的非营利研究机构 根据缅因州法律成立的组织 自1929年以来。 实验室的工作跨越三个重叠的领域， 领域：研究、资源和培训。 研究动物 通过提供高质量的服务， 动物护理和向研究者提供适当的技术援助， 学员和资源人员。 实验动物医学 计划提供全面的兽医，诊断和 监测活动。 此外，遗传质量控制 监测杰克逊实验室小鼠的遗传完整性。 该提案的目的是升级研究动物 设施通过增加22个单位的加压，单独 通风（PIV）笼-配有聚碳酸酯笼， 不锈钢盖、瓶和过滤器/鼓风机模块-和4 移动的HEPA过滤交换站。 这些单位是必需的 研究人员使用免疫缺陷小鼠， 研究项目。 这些遗传性免疫缺陷， 小鼠是免疫缺陷的极好模型， 人类自身免疫性疾病，但研究往往受到阻碍， 这些动物很容易受到感染， 机会主义微生物，即使被安置在 研究动物中普遍存在的异常清洁条件 设施。 为了收集准确的数据并生成 可重复的结果，这些研究人员必须相信， 研究中的免疫反应不是 机会性感染 增加PIV笼将解决 这个问题，并帮助实现研究动物的目标 为所有研究者提供最高质量的设施 动物护理可能