UPGRADING THE RESEARCH ANIMAL FACILITY

杰克逊实验室是一家私人非营利性研究机构 根据缅因州法律注册成立的组织 从1929年开始。该实验室的工作跨越了三个重叠的部分 领域：研究、资源和培训。研究动物 设施通过提供高质量使所有这些领域受益 照顾动物和向调查人员提供称职的技术援助， 实习生和资源人员。实验动物医学 计划提供全面的兽医、诊断和 监控活动。此外，遗传质量控制 监测杰克逊实验室小鼠的遗传完整性。 这项提议的目的是升级研究动物 设施，通过增加22个单位的加压，单独 通风(PIV)笼-配有聚碳酸酯笼， 不锈钢盖、瓶子和过滤器/鼓风机模块--和4 流动HEPA过滤换气站。这些部件是必需的 由研究人员利用免疫缺陷小鼠在他们的 研究项目。这些可遗传的免疫缺陷在 小鼠是免疫缺陷的优秀模型， 人类患有自身免疫性疾病，但研究经常受到 这些动物容易感染的事实是 机会主义微生物，即使在 研究动物中普遍存在的异常清洁的条件 设施。为了收集准确的数据并生成 可重现的结果，这些调查人员必须相信 调查中的免疫反应不是结果 机会性感染的可能性。增加PIV笼子将解决 这一问题有助于实现动物研究的目标 为所有调查人员提供最高质量的设施 照顾动物是可能的。

The Jackson Laboratory is a private not-for-profit research organization incorporated under the laws of the state of Maine since 1929. The work of the Laboratory spans three overlapping areas: research, resource and training. The Research Animal Facility benefits all of these areas by providing high quality animal care and competent technical assistance to investigators, trainees and resource personnel. Laboratory Animal Medicine programs provide comprehensive veterinary, diagnostic and monitoring activities. In addition, Genetic Quality Control monitors the genetic integrity of Jackson Laboratory mice. The aim of this proposal is to upgrade the Research Animal Facility by the addition of 22 units of pressurized, individually ventilated (PIV) caging - complete with polycarbonate cages, stainless steel covers, bottles and filter/blower modules - and 4 mobile HEPA filtered change stations. These units are required by investigators who are using immunodeficient mice in their research programs. These heritable immunological defects in mice are excellent models for immunodeficiency and autoimmunity disease in man, but research is often hampered by the fact that these animals are susceptible to infection by opportunistic microorganisms, even when housed under the exceptionally clean conditions prevailing in the Research Animal Facility. In order to collect accurate data and generate reproducible results, these investigators must be confident that the immunological responses under investigation are not the result of opportunistic infection. The addition of PIV caging will address this problem and help achieve the goal of the Research Animal Facility to provide all investigators with the highest quality animal care possible.