CATECHOLAMINE & BLOOD PRESSURE RESPONSE TO DAILY STRESS

儿茶酚胺

• 批准号: 3449373
• 负责人: GARY D JAMES
• 金额: $ 5.22万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 1989-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3449373
• 关键词: blood pressure; catecholamines; diet; emotions; environmental stressor; epinephrine; female; neuroendocrine system; norepinephrine; patient monitoring device; psychic activity level; psychological stressor; stress; urinalysis

The stress of everyday life is thought to influence blood pressure in a number of ways which include the effects of emotions, diet, physical and mental activity, and other environmental factors. The overall purpose of this study is to examine the relationship among these factors, neuroendocrine activity, and blood pressure during a typical day in a sample of 120 healthy females recruited from the technical and clerical staff at The New York Hospital. Three main questions will be addressed by the research: 1) Does blood pressure follow neuroendocrine activity (as reflected in the levels of urinary catecholamines) during the course of a typical working day? 2) What aspects of daily life contribute most to the variation in blood pressure and neuroendocrine activity?, and 3) How do the factors which influence blood pressure and neuroendocrine activity change and interact over the course of the day? Ambulatory monitoring will be used to measure blood pressure. Timed urine specimens will be collected to measure rates of urinary catecholamines (epinephrine and norepinephrine) excretion. The relationship between and among blood pressure, sympathetic activity, and aspects of daily life will be examined using linear regression and covariance structure models. The results of this study will add to our understanding of how daily stresses contribute to elevations of blood pressure.

日常生活的压力被认为会影响血压， 许多方式，其中包括情绪的影响，饮食，身体和 心理活动和其他环境因素。 的总体目的 本研究旨在探讨这些因素之间的关系， 神经内分泌活动和血压在一个典型的一天， 120名健康女性的样本招募从技术和文书 纽约医院的工作人员。 三个主要问题将由 研究：1）血压是否随神经内分泌活动（如 反映在尿中的儿茶酚胺的水平）的过程中， 典型的工作日？ 2)日常生活中的哪些方面最有助于 血压和神经内分泌活动的变化？（3）如何 影响血压和神经内分泌活动变化的因素 并在一天中进行互动 将使用动态监测来测量血压。 定时尿液 将采集标本以测量尿儿茶酚胺的比率 （肾上腺素和去甲肾上腺素）排泄。 和之间的关系 在血压、交感神经活动和日常生活方面， 使用线性回归和协方差结构模型进行检查。 的 这项研究的结果将增加我们对日常压力是如何 会导致血压升高