DEVELOPMENT OF POLYAMINE ANALOGS AS ANTICANCER AGENTS

作为抗癌剂的聚胺类似物的开发

基本信息

  • 批准号:
    3459331
  • 负责人:
  • 金额:
    $ 8.69万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1990
  • 资助国家:
    美国
  • 起止时间:
    1990-01-01 至 1994-12-31
  • 项目状态:
    已结题

项目摘要

The objectives of the proposed work are to study the effect of the distribution of surface positive charges of polyamines on the interactions with nucleic acids and to use these results to design and synthesize polyamine analogs with modified charge distributions that may have different affinities for nucleic acids than the naturally-occurring polyamines. The analogs should physically replace natural polyamines without duplicating at least some of their biological functions. The specific aims are: 1) to measure the association constants of naturally-occurring polyamines and synthetic polyamine analogs with DNA and polynucleotides using Spectroscopic methods; 2) to determine whether polyamine analogs will mimic the condensation of DNA and/or the induction of the B to Z transition of specific polynucleotides caused by naturally-occurring polyamines; 3) to test the effects of specific analogs on the growth and viability of cultured human and rodent brain tumor cells; 4) to study the effects on the cytotoxicity of CENUs and Cis-Pt caused by replacement of naturally- occurring polyamines with effective analogs previously identified: and, 5) to assist the effects of analogs on DNA crosslinking caused by CENU and cis- Pt. Results obtained in Aims 1 and 2 will be used to choose and design effective analogs, and results from Aims 3-5 will allow evaluation of the effects of analogs on living cells that may lead to the design of therapeutically important anticancer agents.
拟议工作的目标是研究的影响

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Hirak S. Basu其他文献

Polyamine analog bis(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) enhances simian virus 40 late gene expression
  • DOI:
    10.1007/s002800050904
  • 发表时间:
    1999-02-01
  • 期刊:
  • 影响因子:
    2.300
  • 作者:
    Hirak S. Basu;Nancy Dreckschmidt;Linh Tu;Lisa Chanbusarakum
  • 通讯作者:
    Lisa Chanbusarakum

Hirak S. Basu的其他文献

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{{ truncateString('Hirak S. Basu', 18)}}的其他基金

[PQC-3] A Metabolic Pathway Activation Marker for Prostate Cancer Prognosis
[PQC-3] 前列腺癌预后的代谢途径激活标志物
  • 批准号:
    8687192
  • 财政年份:
    2014
  • 资助金额:
    $ 8.69万
  • 项目类别:
Validation of Biomarkers to Distinguish Aggressive from Indolent Prostate Cancer
验证区分侵袭性前列腺癌和惰性前列腺癌的生物标志物
  • 批准号:
    8642164
  • 财政年份:
    2013
  • 资助金额:
    $ 8.69万
  • 项目类别:
Androgen Receptor-JunD Complex Inhibitors to Prevent Prostate Cancer Progression
雄激素受体-JunD 复合物抑制剂可预防前列腺癌进展
  • 批准号:
    8315084
  • 财政年份:
    2012
  • 资助金额:
    $ 8.69万
  • 项目类别:
Mitochondria Targeted Anti-oxidant for Treatment of Prostate Cancer
线粒体靶向抗氧化剂治疗前列腺癌
  • 批准号:
    7483307
  • 财政年份:
    2008
  • 资助金额:
    $ 8.69万
  • 项目类别:
Prostate-Directed Antioxidant to Prevent Prostate Cancer
前列腺定向抗氧化剂可预防前列腺癌
  • 批准号:
    7213330
  • 财政年份:
    2006
  • 资助金额:
    $ 8.69万
  • 项目类别:
Prostate-Directed Antioxidant to Prevent Prostate Cancer
前列腺定向抗氧化剂可预防前列腺癌
  • 批准号:
    7102305
  • 财政年份:
    2006
  • 资助金额:
    $ 8.69万
  • 项目类别:
DEVELOPMENT OF POLYAMINE ANALOGS AS ANTICANCER AGENTS
作为抗癌剂的聚胺类似物的开发
  • 批准号:
    3459329
  • 财政年份:
    1990
  • 资助金额:
    $ 8.69万
  • 项目类别:
DEVELOPMENT OF POLYAMINE ANALOGS AS ANTICANCER AGENTS
作为抗癌剂的聚胺类似物的开发
  • 批准号:
    2093252
  • 财政年份:
    1990
  • 资助金额:
    $ 8.69万
  • 项目类别:
DEVELOPMENT OF POLYAMINE ANALOGS AS ANTICANCER AGENTS
作为抗癌剂的聚胺类似物的开发
  • 批准号:
    3459328
  • 财政年份:
    1990
  • 资助金额:
    $ 8.69万
  • 项目类别:
DEVELOPMENT OF POLYAMINE ANALOGS AS ANTICANCER AGENTS
作为抗癌剂的聚胺类似物的开发
  • 批准号:
    3459330
  • 财政年份:
    1990
  • 资助金额:
    $ 8.69万
  • 项目类别:
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