METALLACYCLOBUTENES, SYNTHESIS AND REACTIVITY

金属酰环丁烯、合成和反应性

• 批准号: 3466789
• 负责人: KENNETH DOXSEE
• 金额: $ 9.95万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-07-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3466789
• 关键词: carbonyl compound; cyanides; drug design /synthesis /production; drug screening /evaluation; heterocyclic compounds; ligands; metal complex; organometallic compounds; sulfoxide

The construction of new carbon-carbon bonds is central to the synthesis of the complex molecules often found to display useful or interesting biochemical or physiological activity. Organotransition metal complexes continue to offer versatile new approaches to bond formation. Metallacyclobutenes react with unsaturated organic substrates such as carbonyl compounds, nitriles, and sulfoxides, yielding organometallic complexes which may be transformed into a wide variety of important heterocyclic organic molecules. The generality and functional group tolerances of these transformations will be explored. Further synthetic applications will be achieved through the synthesis of a series of new metallacyclobutenes, in which systematic variation of the transition metal and of its supporting ligands will permit both coarse and fine tuning of metallacycle reactivity and substrate specificity.

新的碳-碳键的构建是 合成的复杂分子往往发现显示有用的 或有趣的生化或生理活动。 有机过渡金属配合物继续提供多功能的新 形成债券的方法。 金属环丁烯与 不饱和有机底物如羰基化合物， 腈和亚砜，产生有机金属络合物， 可以转化为各种重要的杂环 有机分子 共性与功能群 将探索这些变换的公差。 进一步 合成应用将通过合成 一系列新的金属环丁烯，其中系统变异 过渡金属及其支撑配体的存在将允许 金属镧系元素反应性的粗调和微调， 底物特异性