FETAL CEREBRAL RESPONSE TO SOUND STIMULATION

胎儿大脑对声音刺激的反应

• 批准号: 3470227
• 负责人: CONRAD R CHAO
• 金额: $ 11.5万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-01 至 1993-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3470227
• 关键词: auditory stimulus; behavioral habituation /sensitization; biological models; blood flow measurement; blood pressure; brain metabolism; cardiovascular disorder diagnosis; cerebral ischemia /hypoxia; cerebrovascular disorder diagnosis; clinical chemistry; diagnosis procedure safety; electroencephalography; electromyography; embryo /fetus; embryo /fetus monitoring; gestational age; glucose metabolism; heart rate; lactates; oxygen consumption; perfusion; psychophysiology; respiratory oxygenation; sheep; sound; stimulus /response

The long-term objectives of this project are to characterize the fetal cerebral metabolic and behavioral response to the application of sound during physiologic and pathologic conditions. Although stimulation by sound is rapidly gaining popularity in the clinical obstetric community as a means of fetal assessment, very little is known about its effects on the fetus or the fetal brain. Recent data have suggested that sound stimulation causes marked increases in fetal glucose metabolism throughout the cerebral cortex. In addition, studies in the normally oxygenated adult suggest that stimulation-induced increases in glucose consumption are metabolized anaerobically. Application of sound to the fetus may thus result in local lactate production by the fetal brain which may be deleterious to the fetus. Fetal sheep will be chronically catheterized and microsphere measurements of cerebral blood flow will be made with and without the application of a sound stimulus. Arteriovenous differences for glucose, oxygen, and lactate will be obtained and cerebral net fluxes calculated. In addition, the behavioral response will be assessed by measurement of heart rate, electroencephalogram, and limb and nuchal electromyograms. The development of the cerebral response will be investigated in terms of gestational age. Fetal habituation to the stimulus will be characterized and the metabolic consequences of habituation will be explored. The fetal response to sound will be determined during and after ischemia, a time when a dissociation between behavioral and metabolic responses has been observed in the adult. The goals are a.) to build a base of knowledge of the cerebral metabolic and behavioral responses to sound in order to more fully evaluate the clinical utility and safety of the use of sound as a tool to diagnose fetal well-being and b.) to utilize sound stimulation as a model of sensory activation to determine the contribution of anaerobic metabolism to total glucose consumption during physiologic and pathological circumstances as a result of stimulation.

该项目的长期目标是描述胎儿的特征 对声音应用的大脑代谢和行为反应 在生理和病理条件下。虽然有声音的刺激 作为一种在临床产科界迅速流行的方法 胎儿评估手段，但对其对胎儿的影响知之甚少 胎儿或胎儿大脑。最近的数据表明声音刺激 导致胎儿整个大脑的葡萄糖代谢显着增加 皮质。此外，对正常氧合成人的研究表明 刺激引起的葡萄糖消耗增加被代谢 厌氧地。因此，对胎儿应用声音可能会导致局部 胎儿大脑产生的乳酸可能对胎儿有害 胎儿。胎羊将被长期置入导管并植入微球 脑血流量的测量将在有或没有的情况下进行 应用声音刺激。葡萄糖的动静脉差异， 将获得氧气和乳酸并计算脑净通量。在 此外，将通过测量心脏来评估行为反应 率、脑电图、四肢和颈项肌电图。这 大脑反应的发展将根据以下方面进行研究 胎龄。胎儿对刺激的习惯将被表征 并将探讨习惯化的代谢后果。胎儿 对声音的反应将在缺血期间和之后确定，此时 观察到行为反应和代谢反应之间存在分离 在成人中。目标是 a.) 建立一个知识基础 大脑对声音的代谢和行为反应，以便更充分地 评估使用声音作为工具的临床效用和安全性 诊断胎儿健康状况 b.) 利用声音刺激作为模型 感觉激活以确定无氧代谢的贡献 生理和病理过程中总葡萄糖消耗 因环境刺激而产生的结果。