SURGICAL STUDIES ON METABOLISM OF G I HORMONES
G I 激素代谢的外科研究
基本信息
- 批准号:3483096
- 负责人:
- 金额:$ 30.58万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1976
- 资助国家:美国
- 起止时间:1976-05-01 至 1994-04-30
- 项目状态:已结题
- 来源:
- 关键词:Zollinger Ellison syndrome acinar cell athymic mouse bile birth bombesin calcium cholecystokinin cyclic nucleoside monophosphate diet digestion dogs esophagogastric junction fasting female gallbladder gastric inhibitory peptide gastric juice gastric mucosa gastrointestinal hormones gastrointestinal motility /pressure gastrointestinal pharmacology gastrointestinal system glucagon goats guinea pigs hamsters high performance liquid chromatography hormone receptor hormone regulation /control mechanism human pregnant subject human subject indomethacin insulin intestine neoplasm laboratory mouse laboratory rabbit laboratory rat liver metabolism muscle contraction neoplastic growth neurotensin nutrition related tag pancreas disorder pancreas enzyme pancreas neoplasms pancreatic polypeptide peptic ulcer peptide hormone prostaglandins radioimmunoassay radiotracer secretion stomach surgery substance P thyroid disorder thyroid neoplasm tissue /cell culture vagotomy
项目摘要
The objectives of this proposal are to investigate the role of
gastrointestinal hormones (GIH) in the digestive (and related) processes.
We will study the mechanisms for release of neurotensin (NT) from the gut
and from medullary carcinoma of the thyroid. We will determine the effect
of NT on gastric secretion stimulated by different routes. We plan to
characterize cholecystokinin (CCK), NT, bombesin, and peptide YY (PYY) by
HPLC. We will determine the differential hepatic uptake of different
molecular forms of endogenously released CCK by bioassay and
radioimmunoassay. We plan to study the mechanisms of actions of CCK on
gallbladder (GB) smooth muscle. We will study the action of PYY on gastric
secretion and measure PYY receptors in antrum and fundus. We plan to study
the mechanism of relaxation of the sphincter of Oddi by CCK and to
determine, by receptor studies, whether substance P is involved. We will
determine the relationships between the gut and pancreatic acinus and note
particularly the roles of NT, prostaglandins, and indomethacin. We will
use whole animals, isolated pancreas, and dispersed acini. We plan to
characterize the enterinsulinar relationships of GIH and calcium-regulatory
peptides on secretion of insulin and glucagon, to determine whether
intracerebroventricular administration of GI and calcium-regulatory
peptides influence secretion of insulin and glucagon, and to examine the
influence of pregnancy on the relationship between gut hormones and
pancreatic endocrine hormone secretion. We will study the role of GIH in
the inhibition and stimulation of growth of the pancreas and the
relationship with hormone receptors and efficacy of action. We will study
the role of stimulatory and inhibitory peptides in the pathogenesis and
course of experimental acute pancreatitis. We plan to determine the
effects of GIH on the stimulation and inhibition of growth of cancers of
the gut and pancreas. We will measure GIH receptors in gut and pancreatic
cancer cells. We plan clinical studies on the relationship between GIH and
chronic pancreatitis in patients before and after operation. We will
continue our metabolic studies on patients with the Zollinger-Ellison
syndrome (ZES) and plan to compare nutrition after total gastrectomy in ZES
and non-ZES patients. We will study the role of GIH in patients with
thryoid disease. We will study the metabolism of NT in man. We will
determine the effects of various stages of pregnancy, as compared with the
postpartum state, on the relationship between CCK and GB contraction in
women.
本提案的目的是调查以下方面的作用:
胃肠激素(GIH)在消化(及相关)过程中的作用。
我们将研究肠道释放神经降压素(NT)的机制
以及甲状腺髓样癌。 我们将确定
NT对不同途径刺激胃分泌的影响。 我们计划
通过以下方法表征胆囊收缩素(CCK)、NT、蛙皮素和肽YY(PYY):
高效液相色谱法 我们将确定不同的肝脏摄取差异
通过生物测定内源性释放CCK的分子形式,
放射免疫法 我们计划研究CCK的作用机制,
胆囊(GB)平滑肌。 我们将研究PYY对胃粘膜的作用,
分泌和测量胃窦和胃底的PYY受体。 我们计划学习
CCK松弛Oddi括约肌的机制及CCK对Oddi括约肌的影响
通过受体研究确定P物质是否参与其中。 我们将
确定肠道和胰腺腺泡之间的关系,并注意
特别是NT、三尖杉酯碱和吲哚美辛的作用。 我们将
使用整个动物、分离的胰腺和分散的腺泡。 我们计划
描述GIH和钙调节的肠胰岛素关系
肽对胰岛素和胰高血糖素分泌的影响,以确定是否
脑室内胃肠道给药和钙调节
肽影响胰岛素和胰高血糖素的分泌,
妊娠对肠道激素与
胰腺内分泌激素分泌。 我们将研究GIH的作用,
抑制和刺激胰腺生长,
与激素受体的关系和作用效果。 我们将研究
刺激和抑制肽在发病机制中的作用,
实验性急性胰腺炎的过程。 我们计划确定
GIH对刺激和抑制肿瘤生长的作用
肠道和胰腺 我们将测量肠道和胰腺中的GIH受体,
癌细胞 我们计划对胃肠道出血与
慢性胰腺炎患者手术前后。 我们将
继续我们对Zollinger-Ellison综合征患者的代谢研究
ZES综合征患者全胃切除术后营养状况比较
非ZES患者。 我们将研究GIH在以下患者中的作用:
甲状腺疾病 我们将研究NT在人体内的代谢。我们将
确定怀孕的各个阶段的影响,与
产后状态下胆囊收缩素与胆囊收缩的关系
妇女
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
JAMES C THOMPSON其他文献
JAMES C THOMPSON的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('JAMES C THOMPSON', 18)}}的其他基金
SURGICAL RESEARCH TRAINING/GASTROINTESTINE ENDOCRINOLOGY
外科研究培训/胃肠内分泌学
- 批准号:
2135185 - 财政年份:1992
- 资助金额:
$ 30.58万 - 项目类别:
SURGICAL RESEARCH TRAINING/GASTROINTESTINE ENDOCRINOLOGY
外科研究培训/胃肠内分泌学
- 批准号:
2135187 - 财政年份:1992
- 资助金额:
$ 30.58万 - 项目类别:
相似海外基金
Regulation of acinar cell function
腺泡细胞功能的调节
- 批准号:
RGPIN-2018-06444 - 财政年份:2022
- 资助金额:
$ 30.58万 - 项目类别:
Discovery Grants Program - Individual
Regulation of acinar cell function
腺泡细胞功能的调节
- 批准号:
RGPIN-2018-06444 - 财政年份:2021
- 资助金额:
$ 30.58万 - 项目类别:
Discovery Grants Program - Individual
Regulation of acinar cell function
腺泡细胞功能的调节
- 批准号:
RGPIN-2018-06444 - 财政年份:2020
- 资助金额:
$ 30.58万 - 项目类别:
Discovery Grants Program - Individual
Elucidation of the developmental mechanism of pancreatic acinar cell metaplasia in stomach
胃胰腺腺泡细胞化生发育机制的阐明
- 批准号:
20K16985 - 财政年份:2020
- 资助金额:
$ 30.58万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Research on carcinogenesis and cell differentiation using established human pancreatic acinar cell carcinoma cell line
利用已建立的人胰腺腺泡细胞癌细胞系进行癌发生和细胞分化的研究
- 批准号:
19K07518 - 财政年份:2019
- 资助金额:
$ 30.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Characterization of SPCA2C in acinar cell function
SPCA2C 在腺泡细胞功能中的表征
- 批准号:
539767-2019 - 财政年份:2019
- 资助金额:
$ 30.58万 - 项目类别:
University Undergraduate Student Research Awards
Regulation of acinar cell function
腺泡细胞功能的调节
- 批准号:
RGPIN-2018-06444 - 财政年份:2019
- 资助金额:
$ 30.58万 - 项目类别:
Discovery Grants Program - Individual
The study to detect early-stage pancreatic cancer based on the data from molecular biology about the atrophic acinar cell surrounding carcinoma in situ.
该研究基于原位癌周围萎缩性腺泡细胞的分子生物学数据来检测早期胰腺癌。
- 批准号:
18K07897 - 财政年份:2018
- 资助金额:
$ 30.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Regulation of acinar cell function
腺泡细胞功能的调节
- 批准号:
RGPIN-2018-06444 - 财政年份:2018
- 资助金额:
$ 30.58万 - 项目类别:
Discovery Grants Program - Individual
Investigation of the role of BRG1 in acinar cell-derived pancreatic tumorigenesis
BRG1 在腺泡细胞源性胰腺肿瘤发生中的作用研究
- 批准号:
17H06805 - 财政年份:2017
- 资助金额:
$ 30.58万 - 项目类别:
Grant-in-Aid for Research Activity Start-up