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ISOLATION OF PROTEOLYTIC ANTIBODIES IN E COLI

ISOLATION OF PROTEOLYTIC ANTIBODIES IN E COLI
大肠杆菌中蛋白水解抗体的分离
批准号:
3489647
负责人:
Alan Greener
金额:
$4.93万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1993
资助国家:
美国
项目状态:
已结题
起止时间:
1993-01-15 至 1993-07-14

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中文摘要
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英文摘要
The objective of this proposal is to isolate antibody molecules capable of proteolytic cleavage of their cognate antigen. An E. coli selection system has been devised to identify these antibodies. Large antibody libraries can be made and screened in E. coli using the ImmunoZapTM technology, and this directed approach to the isolation of rare antibodies with proteolytic activity may lead to new types of therapeutic agents for combating certain infections and diseases.
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