ULTRASOUND/COLLAGEN TREATMENT OF FULL THICKNESS WOUNDS

慢性伤口是一个主要的卫生保健问题，消耗超过100亿美元 每年的治疗费用。 我们建议进行可行性研究， 超声辐照与胶原蛋白协同作用 治疗，基于他们的独立行动的知识， 加速和协助伤口愈合过程。 实验 该方法将使用精心设计的校准超声暴露 系统 直径为1.5 cm的全层伤口将用于 成年猪模型，实验持续时间为21天（从初始 对最终测定的损伤）。 该方案将涉及三个不同的小组： 1)a胶原蛋白珠悬浮治疗，2）Duoderm TM的应用 （水胶体敷料），和3）非反应溶液（等渗缓冲液 盐水）。 每组将有一个相应的对照品， 超声暴露（共6组）。 六头猪每头都有九头 伤口部位，每天超声暴露5分钟，以及 每天重复胶原蛋白的应用，直到完全颗粒化。 伤口分析 将包括：伤口尺寸测量、肉芽化程度、水蒸气 在损伤后第7、14和21天进行透射和组织学研究。 如果成功，这项研究将开辟一条新的、具有成本效益的途径， 良好的伤口处理

Chronic wounds ar a major health care problem, consuming over $10 billion annually in treatment costs. We are proposing a feasibility study into the synergistic effects of combining ultrasound insonation and collagen treatments, based on the knowledge of their independent action in accelerating and assisting the would healing process. The experimental approach will use a carefully designed an calibrated ultrasound exposure system. Full thickness wounds of 1.5 cm in diameter will be used in an adult pig model, with an experimental duration of 21 days (from initial injury to final assay). The protocol will involve three different groups: 1) a collagen bead suspension treatment, 2) the application of Duoderm TM (hydrocolloid dressing), and 3) a nonreacting solution (isotonic buffered saline). Each group will have a corresponding control not subjected to ultrasound exposure (six groups total). Each of six pigs will have nine wound sites, with daily ultrasound exposure for five minutes per day, and repeat collagen application daily until fully granulated. Wound analysis will include: wound size measurement, extent of granulation, water vapor transmission, and histological studies on days 7, 14 and 21 post-injury. If successful, this research will open up a new, cost-effective avenue of sound wound management.