ASBESTOS TOXICITY AND CARCINOGENICITY

这项研究的长期目标是降低毒性 和致癌性的石棉通过去铁胺治疗， 中和了含石棉的铁的催化活性。 在该项目的第一阶段，去铁胺 治疗可以减少石棉引起的鳞状上皮化生， 将研究气管器官培养物。 鳞状上皮化生是 被认为先于导致致癌的变化。 同相 去铁胺保持与石棉结合的能力， 长期也将受到考验。 今后，在第二阶段， 将给予去铁胺处理和未处理的石棉 对大鼠和恶性肿瘤的长期发病率将是 测定了 这项研究不仅将测试去铁胺的能力， 以减少石棉毒性，但也将测试电流 假设石棉的毒性和致癌性是 部分由于铁催化产生高反应性的 氧自由基 这种去铁胺治疗可以广泛用作 石棉前进行的标准化学清洗处理 从建筑物中拆除或在石棉 存在。 因此，如果有效的话， 为清除石棉而感染与石棉有关的疾病， 其他工人。 在商业上，这可能代表着一个非常大的 市场，因为石棉从学校，家庭和其他 建筑物已成为许多社区的高度优先事项。

The long range objective of this research is to reduce the toxicity and carcinogenicity of asbestos by desferroxamine treatment, which neutralizes the catalytic activity of the asbestos-contained iron. In phase I of this project the possibility that desferroxamine treatment can reduce asbestos-caused squamous metaplasia in tracheal organ cultures will be studied. Squamous metaplasia is thought to precede changes that lead to carcinogenesis. In phase I, the ability of desferroxamine to remain bound to asbestos for long periods will also be tested. In the future, under phase II, desferroxamine-treated and untreated asbestos will be administered to rats and the long-term incidence of malignancy will be measured. This study will not only test desferroxamine's ability to reduce asbestos toxicity but will also test a current hypothesis that the toxicity and carcinogenicity of asbestos is due, in part, to iron-catalyzed generation of highly reactive oxygen radicals. This desferroxamine treatment could be used widely as part of the standard chemical washing treatment performed prior to asbestos removal from buildings or prior to working in areas where asbestos is present. This could therefore, if effective, reduce the risk of contracting asbestos-related diseases for asbestos-removal and other workers. Commercially, this could represent a very large market since asbestos removal from schools, homes, and other buildings has become a high priority in many communities.