COMPACT DIODE-PUMPED LASER SYSTEM FOR BIOMEDICAL IMAGING

用于生物医学成像的紧凑型二极管泵浦激光系统

• 批准号: 3493380
• 负责人: FRANK ADAMS
• 金额: $ 4.79万
• 依托单位: LIGHTWAVE ELECTRONICS CORPORATION
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-07 至 1994-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3493380
• 关键词: biomedical equipment development; clinical biomedical equipment; heterodyning; imaging /visualization /scanning; lasers; light scattering; optics; tissues

Lightwave Electronics Corporation proposes to develop a compact diode-pumped laser system for non-ionizing imaging of soft tissue. The concept works as follows. Two single-frequency lasers, when aligned and overlapping onto a photodiode, create a heterodyne signal in the detector proportional to each beam's amplitude. A scattering medium placed in one beam's path scatters light outside of the beam so that the heterodyne signal results only from unscattered light. If a dense embedded object attenuates the beam, the heterodyne signal decreases and the object can be imaged. Additionally, the frequency of the heterodyne signal allows the use of an extremely sensitive detection system, which allows for imaging through thicker samples. Lightwave has demonstrated this concept in a simple setup using two single frequency diode-pumped Nd:YAG lasers. The goals of the Phase I program are to explore the limits of this system by optimizing the signal detection system, exploring other possible laser systems or configurations, and measuring systems characteristics such as spatial resolution, signal-to-noise ratio, and data acquisition rates. At the completion of the Phase I we expect to be able to generate two dimensional images through tissue samples. During Phase II we expect to develop a complete prototype imaging system.

光波电子公司建议开发一种紧凑的 用于软组织非电离成像的二极管泵浦激光系统。 的 概念工作如下。两个单频激光器，当对准时， 叠加到光电二极管上，在检测器中产生外差信号， 与每个光束的振幅成比例。 一种散射介质， 光束的路径散射光束外部的光， 信号仅由非散射光产生。 如果密集嵌入对象 衰减光束，外差信号减小，并且物体可以 被成像。 此外，外差信号的频率允许 使用极其灵敏的检测系统， 通过较厚的样品成像。 Lightwave在一个简单的设置中演示了这一概念， 单频二极管泵浦Nd：YAG激光器。 第一阶段的目标 计划是探索这个系统的限制，通过优化信号 探测系统，探索其他可能的激光系统或 配置和测量系统特性，如空间 分辨率、信噪比和数据采集速率。 在 第一阶段完成后，我们预计将能够产生两个 通过组织样本的三维图像。 在第二阶段，我们希望 开发完整的原型成像系统。