MINIATURE SOLID-STATE PUMPS FOR BIOMEDICINE

该建议涉及一种新型泵的开发， 生物医药 该泵是一种小型压电装置， 传统的移动部件，并且整体尺寸仅为几毫米。 数字 电脉冲产生单独的泵送“冲程”，并且泵可以 可以在高达20，000赫兹的频率下工作。 在我们的原型中，每一个脉冲 大约51 pl的流体;建模研究表明， 可以生产更小的体积。 微型尺寸，精确的体积控制， 数字操作使压电泵成为一个有吸引力的候选人， 许多生物医学应用。 初步研究表明， 在实验室工作，将液体泵入细胞或组织， 也可以在植入体腔后工作， 组织或器官。 泵的设计是从喷墨技术发展而来的， MicroFab。 这些喷嘴由一个内部玻璃毛细管组成， 由压电外壁包围的精密成形的孔口， 电子激活时的合同。 本工作将（i）表征粘性流体动力学行为 这是我们设备中泵送的基础，（ii）确定最佳泵送 形状和表面的泵送，和（iii）建立和评估原型 泵.

This proposal concerns the development of a new kind of pump for biomedicine. The pump is a small, piezoelectric device that has no conventional moving parts and is only a few mm in overall size. Digital electrical pulses produce individual pumping "strokes," and the pump can be operated at up to 20,000 hz. In our prototype, each pulse delivers approximately 51 pl of fluid; modeling studies indicate that larger and smaller volumes can be produced. The combination of miniature size, precise volumetric control, and digital operation make the piezoelectric pump an attractive candidate for many biomedical applications. Pilot studies indicate that the pumps will work in the laboratory, to pump fluids into cells or tissues, and would also work after implantation into body cavities, to pump fluids directly into tissues or organs. The pump design has evolved from the ink-jet technology utilized at MicroFab. These jets consist of an inner glass capillary tube with a precision-formed orifice surrounded by a piezoelectric outer wall that contracts when activated electronically. The present work will (i) characterize the viscous hydrodynamic behavior that underlies the pumping in our devices, (ii) determine optimum pump shapes and surfaces for pumping, and (iii) build and evaluate prototype pumps.