THERAPEUTIC ENZYMES FOR DISEASES INVOLVING ACTIVE OXYGEN
THERAPEUTIC ENZYMES FOR DISEASES INVOLVING ACTIVE OXYGEN
批准号:
3500716
负责人:
ABRAHAM ABUCHOWSKI
金额:
$4.68万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1985
资助国家:
美国
项目状态:
已结题
起止时间:
1985-09-01 至 1986-02-28
中文摘要
活性氧类与许多疾病有关。Enzon正在改善
超氧化物歧化酶与过氧化氢酶联合治疗的疗效观察
专利工艺,使这些活性氧清除酶可以使用
例行公事地对抗酸性氧引起的或加重的病理。这个
经过改良的酶正在接受一系列的毒理学测试
目的是为他们获得研究中的新药编号
并启动临床研究。
英文摘要
Active oxygen species are implicated in many diseases. Enzon is improving
the therapeutic effectiveness of superoxide dismutase and catalase by our
patented process so that these active oxygen scavenging enzymes can be used
routinely against acive oxygen-induced or exacerbated pathologies. The
improved enzymes are being submitted to a battery of toxicological tests
with the objective of obtaining investigational New Drug numbers for them
and initiating clinical studies.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
Ca2+ channels in rat central and peripheral neurons: high-threshold current resistant to dihydropyridine blockers and omega-conotoxin.
大鼠中枢和外周神经元中的 Ca2 通道:高阈值电流对二氢吡啶阻滞剂和 omega-芋螺毒素具有抵抗力。
DOI:
10.1016/0896-6273(91)90362-4
发表时间:
1991
期刊:
Neuron
影响因子:
16.2
作者:
[Regan,LJ, Sah,DW, Bean,BP]
通讯作者:
Bean,BP
Safety evaluation of free radical scavengers PEG-catalase and PEG-superoxide dismutase.
自由基清除剂PEG-过氧化氢酶和PEG-超氧化物歧化酶的安全性评价。
DOI:
10.1016/s0748-5514(86)80011-3
发表时间:
1986
期刊:
Journal of free radicals in biology & medicine
影响因子:
--
作者:
[Viau,AT, Abuchowski,A, Greenspan,S, Davis,FF]
通讯作者:
Davis,FF
ENZYME THERAPY FOR DISEASES INVOLVING ACTIVE OXYGEN
-
批准号:3508471
-
项目类别:
-
资助金额:$22.26万
-
财政年份:1988
-
负责人:ABRAHAM ABUCHOWSKI
-
依托单位:
THERAPEUTIC URICASE FOR URIC ACID - INDUCED PATHOLOGIES
-
批准号:3495585
-
项目类别:
-
资助金额:$4.29万
-
财政年份:1986
-
负责人:ABRAHAM ABUCHOWSKI
-
依托单位: