PROTON MICROPROBE FOR TRACE ELEMENT ANALYSIS OF TISSUE

几种人体微量元素的质子微探针研究进展 疾病已经显示出质子的优越性相比， 电子探针这在研究中得到了戏剧性的证明 铝在阿尔茨海默病中的作用 第一阶段工作的目标是设计一个光束聚焦系统， 0.3微米分辨率（相当于电子探针），至少 100皮安的电流这些目标已经被超越，我们可以 实现0. I微米分辨率，至少100皮安的电流。 第二阶段工作的目标是完成工程设计 获取所有组件，组装系统并在 除了我们实验室里的一束光束之外。聚焦系统 将安装在佛罗里达大学的货车德格拉夫 加速器和委托与2.5兆电子伏质子束。像差和 将分别测量和优化分辨率。初步 将使用生物组织进行测量以建立扫描 产生可接受的组织损伤的速率。 这台仪器的空间分辨率提高了3倍， 比电子探针更高的元素灵敏度，具有上级 在生物学研究的许多领域取得突破的潜力， 材料科学

Recent proton microprobe studies on trace elements in several human disorders have shown the superiority of the proton as compared to the electron microprobe. This has been dramatically demonstrated in the studies of aluminum in Alzheimer's disease. The objective of the Phase I work was to design a beam-focusing system with 0.3 micron resolution (comparable to an electron microprobe) and at least 100 picoamperes of current. These goals have been surpassed, and we can achieve 0. I microns resolution with at least 100 picoamperes of current. The objectives of the Phase II work are to complete an engineering design of the system, acquire all components, assemble the system and test it in all regards other than with a beam in our laboratory. The focusing system will then be installed at the University of Florida Van de Graaff accelerator and commissioned with the 2.5 MeV proton beam. Aberrations and resolutions will be measured and optimized respectively. Preliminary measurements with biological tissue will be performed to establish scan rates that produce acceptable tissue damage. This instrument, with 3 times greater spatial resolution and 100 times greater elemental sensitivity than an electron microprobe, has superior potential for breakthroughs in many areas of research in biology and material science.