PROTON MICROPROBE FOR TRACE ELEMENT ANALYSIS OF TISSUE

用于组织微量元素分析的质子微生物探针

• 批准号: 3509243
• 负责人: MOHAMMAD W KATOOT
• 金额: $ 11万
• 依托单位: NANOPTICS, INC.
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-01-01 至 1992-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3509243
• 关键词: analytical method; magnetism; particle accelerators; proton beam; trace elements

Recent proton microprobe studies on trace elements in several human disorders have shown the superiority of the proton as compared to the electron microprobe. This has been dramatically demonstrated in the studies of aluminum in Alzheimer's disease. The objective of the Phase I work was to design a beam-focusing system with 0.3 micron resolution (comparable to an electron microprobe) and at least 100 picoamperes of current. These goals have been surpassed, and we can achieve 0. I microns resolution with at least 100 picoamperes of current. The objectives of the Phase II work are to complete an engineering design of the system, acquire all components, assemble the system and test it in all regards other than with a beam in our laboratory. The focusing system will then be installed at the University of Florida Van de Graaff accelerator and commissioned with the 2.5 MeV proton beam. Aberrations and resolutions will be measured and optimized respectively. Preliminary measurements with biological tissue will be performed to establish scan rates that produce acceptable tissue damage. This instrument, with 3 times greater spatial resolution and 100 times greater elemental sensitivity than an electron microprobe, has superior potential for breakthroughs in many areas of research in biology and material science.

几种人体微量元素的质子微探针研究近况 无序现象已经显示出质子的优越性。 电子微探针。这一点在研究中得到了戏剧性的证明。 阿尔茨海默氏症中的铝。 第一阶段工作的目标是设计一种光束聚焦系统， 0.3微米分辨率(相当于电子探针)，至少 100皮安培的电流。这些目标已经超过，我们可以 达到0。分辨率为1微米，电流至少为100皮安。 第二阶段工作的目标是完成一项工程设计 获取系统的所有组件，组装系统并在 除了我们实验室里的一根横梁外，一切都是如此。调焦系统 然后将安装在佛罗里达大学范德格拉夫 加速器，并委托使用2.5 MeV的质子束。像差和 将分别测量和优化分辨率。初步 将对生物组织进行测量以建立扫描 产生可接受的组织损伤的比率。 这台仪器，空间分辨率提高了3倍，100倍 比电子探针更高的元素灵敏度，具有更好的 在生物学和生物科学研究的许多领域取得突破的潜力 材料科学。