THERMAL GENERATION SYSTEM FOR A NOVEL TTS

描述：(改编自申请人的摘要)机械 新型脉冲透皮治疗系统(TTS)的研制 本提案中所描述的。TTS将使用Intlimer TM聚合物 兰迪克实验室专有的薄膜和热信号发生器，以 开车送他们。因为这种膜的渗透性很低 多种药物低于“开关温度”和极高的通透性 在这个温度以上，药物的释放可以被激活和控制。 通过微小的热刺激来改变膜的状态。系统 有可能有多种给药方案。从这样的服务中获益 系统包括减少耐受性，提高患者依从性，以及 病人控制疗法。 这项提议的重点是开发一种提供热量的系统 激活Intlimer TM膜所需的刺激。这项研究将 包括对适用于这一概念的供暖技术的回顾。一个 将使用最合适的加热方法建造原型 使用Intlimer TM聚合物。该样机将通过以下方式进行评估 关于响应时间、温度控制等参数。 最后，热加热原型将被层压成透皮 带有药物储存库的装置。一种药物的释放情况 对热刺激的反应将在体外进行监测。

DESCRIPTION: (Adapted from the Applicant's Abstract) The mechanical development of a novel pulsed transdermal therapeutic system (TTS) is described in this proposal. The TTS will utilize Intelimer TM polymeric membranes, proprietary to Landec Labs., and a thermal signal generator to drive them. Because the membranes have a very low permeability to a variety of drugs below a "switch temperature" and a very high permeability above that temperature, the release of a drug can activated and controlled by a small heat stimulus to change the state of the membrane. The system has potential for many dosing regimens. Benefits derived from such a system include the reduction of tolerance, improved patient compliance, and patient controlled therapy. This proposal focused on the development of a system to provide the heat stimulus required to activate the Intelimer TM membrane. The research will encompass a review of heating technologies appropriate to this concept. A prototype using the most appropriate heating method will be constructed using the Intelimer TM polymers. This prototype will be evaluated with respect to response time, temperature control, and other parameters. Finally, the thermal heating prototype will be laminated into a transdermal device complete with a drug reservoir. The release profile of a drug as it responds to the heat stimulus will be monitored in vitro.