EXPANDABLE LASERPROBE FOR TREATMENT OF CORONARY DISEASE

该项目的具体目标是设计、建造和 可扩展激光探头在动物实验中的疗效评价 闭塞性冠状动脉和外周动脉疾病。建议数 预计激光探测器将允许合适的患者接受 微创血管疏通术治疗闭塞血管 腿部和心脏的疾病。这可能会导致大量 给患者带来好处，并显著降低医疗成本 照顾这一病症。 建议的设备提供了受控应用的手段 对动脉粥样硬化组织进行加热和加压。三、原则 运行包括将激光能量从源传输到 病人，以及这种能量迅速转化为可控的 探头远端的热能。当接触到 对于闭塞组织，这种探头允许热传导 快速到达这个组织，同时保持已知的压力 探头-组织界面。这导致了选择性和可控性 以最小的热效应消融闭塞组织 周围的组织。 基本设计目标是创建一种可扩展激光探头 它可以经皮引入，也可以单独引入 产生足够大的管腔以允许足够的流量 通过冠状动脉和外周动脉。的初始大小。 激光探头预计约为1.5毫米。这个 生成的通道的目标大小约为5 毫米。

The specific aim of this project is to design, construct, and evaluate in animal an expandable Laserprobe for treatment of occlusive coronary and peripheral artery disease. The proposed Laserprobe is expected to allow suitable patients to undergo a minimally invasive procedure for the relief of occlusive vessel disease in the legs and in the heart. This can result in substantial benefit to the patient and significant reduction in cost of health care for this ailment. The proposed device provides means for controlled application of heat and pressure to atherosclerotic tissue. The principle of operation involves the transmission of laser energy from source to patient, and the rapid conversion of this energy into controlled thermal energy at distal end of probe. When brought into contact with occlusive tissue, this probe allows heat to be conducted rapidly to this tissue while maintaining a known pressure on the probe-tissue interface. This results in selective and controlled ablation of occlusive tissue with minimal thermal effect on surrounding tissue. The basic design objective is to create an expandable laserprobe which can be introduced percutaneously and which can alone generate a sufficiently large lumen to permit adequate flow through coronary and peripheral arteries. The initial size of the laserprobe is expected to be approximately 1.5 millimeters. The target size of the generated channel is approximately 5 millimeters.