EXPANDABLE LASERPROBE FOR TREATMENT OF CORONARY DISEASE

用于治疗冠心病的可扩展激光探头

• 批准号: 3501024
• 负责人: HANY HUSSEIN
• 金额: $ 4.99万
• 依托单位: TRIMEDYNE, INC.
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 1988-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3501024
• 关键词: arteriosclerosis; artery occlusion; biomedical equipment resource; clinical biomedical equipment; fiber optics

The specific aim of this project is to design, construct, and evaluate in animal an expandable Laserprobe for treatment of occlusive coronary and peripheral artery disease. The proposed Laserprobe is expected to allow suitable patients to undergo a minimally invasive procedure for the relief of occlusive vessel disease in the legs and in the heart. This can result in substantial benefit to the patient and significant reduction in cost of health care for this ailment. The proposed device provides means for controlled application of heat and pressure to atherosclerotic tissue. The principle of operation involves the transmission of laser energy from source to patient, and the rapid conversion of this energy into controlled thermal energy at distal end of probe. When brought into contact with occlusive tissue, this probe allows heat to be conducted rapidly to this tissue while maintaining a known pressure on the probe-tissue interface. This results in selective and controlled ablation of occlusive tissue with minimal thermal effect on surrounding tissue. The basic design objective is to create an expandable laserprobe which can be introduced percutaneously and which can alone generate a sufficiently large lumen to permit adequate flow through coronary and peripheral arteries. The initial size of the laserprobe is expected to be approximately 1.5 millimeters. The target size of the generated channel is approximately 5 millimeters.

该项目的具体目标是设计、建造和 在动物身上评估可扩展激光探针治疗 闭塞性冠状动脉和外周动脉疾病。 拟议的 Laserprobe有望让合适的患者接受 缓解闭塞血管的微创手术 腿部和心脏的疾病。 这可能会导致大量 对患者有利并显着降低健康成本 护理这种疾病。 所提出的装置提供了控制应用的手段 动脉粥样硬化组织的热量和压力。 原理 操作涉及将激光能量从源传输到 患者，并将这种能量快速转化为受控的 探头远端的热能。 当接触时 对于闭塞组织，该探头可以传导热量 快速到达该组织，同时保持已知的压力 探针-组织界面。 这导致选择性和受控 以最小的热效应消融闭塞组织 周围组织。 基本设计目标是创建可扩展的激光探针 可以经皮引入，也可以单独引入 产生足够大的内腔以允许足够的流量 通过冠状动脉和外周动脉。 的初始大小 LaserProbe 预计约为 1.5 毫米。 这 生成通道的目标大小约为 5 毫米。