IDENTIFYING HUMAN HOMOLOGUES OF C. ELEGANS GENE

模式线虫秀丽隐杆线虫的生物学可能是 比任何其他动物物种都更详细地了解。 此外，经典和分子遗传学研究，最近的成功， 克隆（非常接近）整个基因组和启动一个协调一致的 对基因组测序的努力增加了这个系统的价值， 进一步. 从C.优雅是最 这种线虫生物学的基本方面是密切相关的， 在分子水平上，那些在其他动物物种中运作的，包括 伙计 与这一结论相一致的是，大约有一半的基因克隆自 C.已经发现秀丽线虫与先前已知的人类同源， 基因. 其他看似重要的C。秀丽线虫的基因 同源物 这些基因中有许多可能在人类中尚未被发现。 同源物，其鉴定可能对以下研究产生重大影响： 人类疾病：这些基因的改变可能导致 人类疾病的病理生理学 其他同源物可以识别新的人类 成为新的人类治疗剂或提供靶向治疗的基因 筛选新疗法的发现。 目前的目标是 研究的目的是开发工具，系统地识别人类 C.同源物elegans基因

The biology of the model nematode Caenorhabditis elegans is probably understood in more detail than that of any other animal species. Furthermore, classical and molecular genetic studies, the recent success in cloning (very nearly) the entire genome and the initiation of a concerted effort to sequence the genome increase the value of this system even further. A consequential deduction from studies of C. elegans is that most fundamental aspects of the biology of this nematode are closely related, at the molecular level, to those operating in other animal species, including man. Consistent with this conclusion, about half of the genes cloned from C. elegans have been found to be homologous to previously known human genes. Other seemingly important C. elegans genes have no known homologues. Many of these genes are likely to have undiscovered human homologues whose identification can have a substantial impact on studies of human disease: Alterations of these genes may contribute to the pathophysiology of human disease. Other homologues may identify new human genes that become novel human therapeutics or provide target-directed screens for the discovery of new therapeutics. The goal of the present research is to develop tools for the systematic identification of human homologues of C. elegans genes.