ENCAPSULATED PARAMAGNETIC IONS T0 ENHANCE NMR IMAGING

质子核磁共振成像正在迅速成为健康领域的主要诊断工具 关心。该技术提供高分辨率的图像，而无需使用 电离辐射。对比度可以增强诊断能力 试剂，如顺磁离子，只要它们是定点定向的并显示 低毒。磷脂小泡(脂质体)是一种细小的亚微观结构。 可封装和局部化顺磁的壳状结构 体内某些组织内的物质。 这项工作的目的是确定诱捕的程度 顺磁离子改变质子弛豫速率(与图像对比度有关) 对于已知有明显囊泡吸收的组织。特别的 感兴趣的是评估某些囊泡制剂，这些制剂具有显著的 至少10种小鼠肿瘤类型的摄取。在某些情况下， 放射性标记囊泡总注射剂量的15%累积在 肿瘤。 如果成功，这项研究为改进提供了一个新的机会 核磁共振成像的诊断特异性。除了有针对性的或 改变生物分布，造影剂很可能会出现在水泡中 表现出较低的毒性。这些优势加上较低的风险 患者通过核磁共振成像代表了一种巨大的、非常有用的商业 满足放射科医生长期需求的企业。

Proton NMR Imaging is rapidly becoming a major diagnostic tool in health care. The technique offers high resolution images without the use of ionizing radiation. Diagnostic capability can be enhanced with Contrast Agents, such as paramagnetic ions, provided they are site-directed and show low toxicity. Phospholipid Vesicles (liposomes) are small submicroscopic shell-like structures which can encapsulate and localize paramagnetic materials within certain tissues in the body. The aim of this work is to determine the extent to which entrapped paramagnetic ions alter proton relaxation rates (related to image contrast) for tissue known to have marked uptake of vesicles. Of particular interest, is evaluating certain vesicle formulations which have significant uptake by at least ten murine tumor types. In some instances, as much as 15% of the total injected dose of radiolabeled vesicle have accumulated in the tumor. If successful, the research offers a new opportunity for improving diagnostic specificity with NMR imaging. In addition to targeted or altered biodistribution, contrast agents in vesicles will very likely exhibit lower toxicity. These advantages coupled with the low risk to patients by NMR imaging represent a large and very useful commercial enterprise fulfilling a long standing need by radiologists.