Cloud-ready analysis methods and software to study effects of DNA variants on single-cell gene expression

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Studying the effects of DNA variants in single cells will advance our understanding of healthy and diseased cell states. We will develop statistical methods to study the effects of DNA variants on gene expression in individual cells, both across large numbers of people and in cancerous cell populations within an individual. Single-cell analyses require large computational resources so we will produce software that can be used easily by all researchers on cluster and cloud computing platforms.