ORGANOSILICON BIOMEDICAL RESEARCH

有机硅生物医学研究

• 批准号: 3936683
• 负责人: CLIFFORD L SMITH
• 金额: --
• 依托单位: ALBANY STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3936683
• 关键词: carbonyl compound; chemical bond; chemical cleavage; chemical reaction; chemical structure function; chemical synthesis; cyclic compound; cytotoxicity; drug administration routes; ethers; halocarbon compound; laboratory mouse; silicon

The specific aim is to investigate the Pharmacological properties of silylated derivatives of known active organic molecules and to identify biologically active organosilicon compounds that do not have known carbon analogy. Active organosilicon compounds without carbon analogy appears to offer the greatest potential for future discovery of new medicinal compounds. The branched-chain organosilicon compounds with three or four silyl groups directly bonded to a carbon or silicon atom have no analogy in organic chemistry, therefore, considerable efforts will be devoted to studies of their activity. Also, synthesis and pharmacology of silylated derivatives of known medicinal . compounds will be investigated to establish correlations between the effect of the space-filling, lipophilic silyl groups and biological properties.

具体目的是研究其药理性质