Cluster randomised trial comparing one versus two doses of ivermectin for mass drug administration to control scabies

疥疮是发展中国家，特别是太平洋地区的一种常见皮肤病。在所罗门群岛西部省，每两个儿童中就有一个患有这种疾病，占人口的20%。我们知道，两剂口服伊维菌素的大规模用药可有效减轻社区中的疥疮负担。我们现在提议进行一项研究，以确定单次剂量是否同样有效。这将对公众健康产生重大好处。

Scabies is a common skin disease in developing countries, in particular in the Pacific region. In the Western Province of Solomon Islands, one in two children suffer from the infestation, and 20% of the population. We know that mass drug administration with two doses of oral ivermectin is effective to reduce the burden of scabies in the community. We now propose a study to determine whether one single dose is as effective. This would have major public health benefits.