BIOMEDICAL CYCLOTRON

这项建议是为了配套资金购买一个新的回旋加速器， 取代我们现有的21岁的生物医学回旋加速器， 到它的先进的年龄和过时的技术。 回旋加速器提供了 我们资助的研究所需的正电子标记化合物 正常人脑的生化和生物机制 发育和神经元可塑性，包括代偿性 脑损伤、疾病或手术后的脑重组。 是 对我们研究儿童发育障碍至关重要。和成人 癫痫、阿尔茨海默病、帕金森病、亨廷顿病、抑郁症/躁狂症、药物 滥用，冠状动脉疾病，心肌病和癌症， 胸、肺、骨、脑、肝和消化系统。 未经 回旋加速器，这将是不可能的，我们继续任何这些资助 研究项目。 这些项目每年涉及NIH约320万美元， 340万美元的能源部资助的研究，所有这些都是完全依赖 回旋加速器设施 我们已经筹集了所需资金的88.6%， 通过获得设备的重大折扣， 供应商，从能源部获得补充赠款，并征求私人 捐赠 由于能源部资助了很大一部分研究 在回旋加速器的项目中，我们要求并收到了908，000美元。 在 此外，我们还从Ahmanson基金会获得了455，000美元， 这次购买。 现有的研究赠款将提供 回旋加速器的必要维护和操作支持。 回旋加速器的管理由一名资源管理员执行。 拨款委员会（RAC），由主要赠款的首席研究员组成 以及技术组件的代表（即，回旋 化学、PET扫描仪和动物实验室）。 这一行政 该配置已生效15年，并有效地 分配回旋加速器和其他主要仪器的资源。

This proposal is for matching funds to purchase a new cyclotron to replace our existing 21 year old biomedical cyclotron that is failing due to its advanced age and obsolete technology. The cyclotron provides all the necessary positron labeled compounds for our funded research studies of the biochemical and biological mechanisms of normal human brain development and neuronal plasticity, including the compensatory reorganization of the brain following injury, disease or surgery. It is critical to our studies of developmental disorders, pediatric. and adult epilepsy, Alzheimer's, Parkinson's, Huntington's, depression/mania, drug abuse, coronary artery disease, cardiomyopathies and cancer of the breast, lung, bone, brain, liver and lymphic system. Without the cyclotron, it would be impossible for us to continue any of these funded research projects. These projects involve approximately $3.2 million per year of NIH and $3.4 Million of DoE funded research all of which are completely dependent upon the cyclotron facility. We have raised 88.6 % of the required funding by obtaining a significant discount on the equipment from the vendor, obtaining a supplementary grant from DoE and soliciting private donations. Since DoE funds a significant fraction of the research projects with the cyclotron, we requested and received a $908,000. In addition, we also obtained $455,000 from the Ahmanson Foundation to apply to this purchase. The existing research grants will provide the necessary maintenance and operating support for the cyclotron. The administration of the cyclotron is carried out by a Resource Allocation Committee (RAC) that consists of the PIs of the major grants and representatives of the technology components (i.e., cyclotron chemistry, PET scanners and animal laboratories). This administrative configuration has been in effect for 15 years and has efficiently allocated the resources of the cyclotron and other major instruments.