MOLECULAR STUDIES USING A PEPTIDE SYNTHESIZER

该提案请求BRS共享仪器计划支持 全自动多肽合成仪器，将用于 新一代抗体试剂的开发 专门识别单独的蛋白质。这些试剂效力很强 将用于这种基础的分子研究的工具 生物现象作为免疫反应的调控因素，协调基因 调控，组织特异性基因表达，基因调控 发育、病毒复制、肿瘤发生、激素调节、化学 真核生物的致癌和蛋白质合成。仪器仪表 将推动分子理性疗法的发展 治疗各种疾病，如癌症、自身免疫性疾病和病毒 感染。

This proposal requests support from the BRS Shared Instrument Program for automated peptide synthesis instrumentation which will be used in the development of a "new generation" of antibody reagents which can specifically identify individual proteins. These reagents are powerful tools which will be used in molecular studies of such fundamental biological phenomena as control of the immune response, coordinate gene regulation, tissue specific gene expression, gene regulation during development, viral replication, oncogenesis, hormonal regulation, chemical carcinogenesis and protein synthesis in eukaryotes. The instrumentation will advance the development of molecularly rational therapies in the treatment of various diseases such as cancer, autoimmune diseases and viral infections.