V G ANALYTICAL V G 70-250 SE

该提案要求30万美元用于购买VG 70- 250 SE质谱仪，以取代10岁的Kratos MS 25 S。 共享仪器将被安置在新的质量 光谱实验室在月桂高地校区的 加州大学旧金山分校弗朗西斯科。 乔治教授 凯尼恩，制药部主席 加州大学旧金山分校的化学专业，也是质谱分析的常客， 将担任首席研究员和咨询委员会主席 以马克思 阿诺德·法利克博士， 生物医学研究资源质谱设施，将 负责仪器的日常监督。 的 主要用户组由NIH的11名研究人员组成 赞助的研究兴趣。 建议侧重于结构 生物复合糖体系分析 重要性和合成，代谢，和毒性的各种 异生物质 所要求的主要理由是 工具是需要建立最先进的能力， 毛细管柱气相色谱/质谱法， 强调高分辨率化学电离。 解决问题 应用程序将提供关键的结构信息， 分子存在于复杂的混合物中， 浓度. 咨询委员会将负责 共享仪表计划的总体指导， 用于解决调度问题。 高达25%的 仪器时间将可用于来自外部的样本 主要用户群。 主用户组中的成员身份 可在主要研究者批准后实现 经咨询委员会审查。 该大学 承诺购买该仪器超过10万美元 以及一份全面服务合同 长期维护和 维修责任将通过以下方式供资： 大学和用户支持基金。

This proposal requests $300,000 towards the purchase of a VG70- 250SE mass spectrometer to replace a 10 year old Kratos MS25S. The shared instrument will be housed in the new mass spectrometry laboratory at the Laurel Heights Campus of the University of California, San Francisco. Professor George Kenyon, Chairman of the Department of Pharmaceutical Chemistry at U.C.S.F. and a frequent user of mass spectrometry, will serve as Principal Investigator and Chairman of the Advisory Committee. Dr. Arnold Falick, the Deputy Director of the Biomedical Research Resource Mass Spectrometry Facility, will be in charge of the day to day supervision of the instrument. The major user group consists of eleven investigators with NIH sponsored research interests. Proposals focus on the structural analysis of complex carbohydrate systems of biological importance and the synthesis, metabolism, and toxicity of various xenobiotics. The principal justification for the requested instrument is the need to establish a state of the art capability in capillary column gas chromatography/mass spectrometry, with emphasis on high resolution chemical ionization. Problem solving applications will provide critical structural information on molecules present in complex mixtures at a very low concentration. An Advisory Committee will be responsible for the overall guidance of the shared instrumentation program and for the resolution of scheduling problems. Up to 25% of instrument time will be available for samples originating outside the principal user group. Membership in the principal user group can be achieved following approval of the principal investigator with review by the Advisory Committee. The University has committed over $100,000 towards the purchase of the instrument and for a full service contract. Long range maintenance and upkeep responsibilities will be funded through a combination of University and user support funds.