MOLECULAR GRAPHICS WORKSTATION

分子图形工作站

• 批准号: 3520117
• 负责人: WILLIAM L DUAX
• 金额: $ 9.1万
• 依托单位: HAUPTMAN-WOODWARD MEDICAL RESEARCH INST
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-05-16 至 1989-05-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3520117
• 关键词: X ray crystallography; biomedical equipment purchase; chemical models; chemical structure; chemical structure function; computer graphics /printing; computer simulation; computers; protein structure

The research projects underway in the Molecular Biophysics Department of the Medical Foundation of Buffalo involve the use of X-ray crystallography to determine the structures of many different types of molecules of biomedical importance. This type of research requires real-time 3-D computer graphics. Thus, in response to the announcement by NIGMS soliciting applications for Shared Instrumentation Grants, the purchase of an IRIS 3130 computer graphics workstation and the hardware and software necessary to interface this workstation with the Medical Foundation's VAX 8600 computer is proposed. This graphics equipment will allow six principal investigators of seven projects to pursue their goals more effectively. The projects are: "Selectivity and Mechanism of Action of Ionophores", "Molecular Structure of Steroids", "Structural Chemical Studies of Metabolic Phosphates", "Molecular and Electronic Structures of Antifolate Drugs", "Auromomycin: Structural Study of Anticancer Activity", "Site Specific Calcium Blockers - Structural Requirements", and "Crystallographic Studies of Monoclinic Human Insulin."

分子生物物理学正在进行的研究项目 布法罗医学基金会部门涉及使用 X射线晶体学来确定许多不同的 具有生物医学重要性的分子类型。 这种类型的研究 需要实时三维计算机图形。 因此，为了响应 NIGMS征求共享申请的公告 仪器赠款，购买IRIS 3130计算机 图形工作站和必要的硬件和软件， 将此工作站与医学基金会的VAX 8600接口 计算机提出。 这台绘图设备将允许六个 七个项目的主要研究人员，以实现他们的目标 更有效地 这些项目是：“选择性和机制 离子载体的作用”，“类固醇的分子结构”， “代谢磷酸盐的结构化学研究”，“分子 和抗叶酸药物的电子结构”，“金霉素： 抗癌活性“位点特异性钙离子”的结构研究 阻滞剂-结构要求”和“晶体学研究 单斜人类胰岛素"