Combining immune profiling and immunotherapy to tackle human cytomegalovirus infection in transplant patients

结合免疫分析和免疫治疗来应对移植患者的人类巨细胞病毒感染

• 批准号: nhmrc : 1111306
• 金额: $ 21.63万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/combining-immune-profiling-transplant-patients/663174
• 关键词: Combining; immune; profiling; immunotherapy; tackle

The proposed research aims to help transplant patients who are at high risk of cytomegalovirus (CMV) infection, using a treatment called adoptive immunotherapy. I seek to improve the function of patients’ own specialised immune cells (known as T cells) in laboratory and transfer the T cells back into patients, allowing them to better fight the CMV infection. This treatment will improve survival, minimise transplant rejection and reduce the cost associated with anti-viral drugs.

拟议的研究旨在使用一种称为过继免疫疗法的治疗方法来帮助巨细胞病毒（CMV）感染高风险的移植患者。我寻求在实验室中改善患者自身特化免疫细胞（称为 T 细胞）的功能，并将 T 细胞转移回患者体内，使他们能够更好地抵抗 CMV 感染。这种治疗将提高生存率，最大限度地减少移植排斥并降低与抗病毒药物相关的成本。