Combining immune profiling and immunotherapy to tackle human cytomegalovirus infection in transplant patients

这项拟议中的研究旨在使用一种称为过继免疫疗法的治疗方法，帮助那些有巨细胞病毒（CMV）感染高风险的移植患者。我试图在实验室中改善患者自身的特异性免疫细胞（称为T细胞）的功能，并将T细胞转移回患者体内，使他们能够更好地对抗CMV感染。这种治疗将提高生存率，最大限度地减少移植排斥反应，并降低与抗病毒药物相关的费用。

The proposed research aims to help transplant patients who are at high risk of cytomegalovirus (CMV) infection, using a treatment called adoptive immunotherapy. I seek to improve the function of patients’ own specialised immune cells (known as T cells) in laboratory and transfer the T cells back into patients, allowing them to better fight the CMV infection. This treatment will improve survival, minimise transplant rejection and reduce the cost associated with anti-viral drugs.