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Born Slippy: A Tribological Discourse on Hysterosalpingography as a Therapeutic Treatment for Infertile Women

天生滑溜：关于子宫输卵管造影术作为不孕妇女治疗方法的摩擦学论述

基本信息

批准号：
EP/R041407/1
负责人：
Karl Dearn
金额：
$ 32.2万
依托单位：
University of Birmingham
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2018
资助国家：
英国
起止时间：
2018 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FR041407%2F1
关键词：
Born Slippy Tribological Discourse Hysterosalpingography

项目摘要

Blocked fallopian tubes are a common cause of female infertility. When seeking treatment for this, the first stage of any intervention will be a search for tube blockages. This procedure involves inserting a dye into the uterus that can then be used to screen how well the tubes are open using x-ray. This medical technique is called hysterosalpingography. The dye or contrast used is either a poppy seed oil based emulsion or water. A recent study led by Prof. Ben Mol at the University of Adelaide has shown a 10% increase in the rates of pregnancy and births for women who received the oil-based contrast. This is a remarkable result given that more common fertility treatment such as Intrauterine insemination raises pregnancy rates by 1 or 2 %. The underlying mechanisms, however, that explain how fertility is enhanced are not clear. It has been suggested that tubal patency testing with an oil contrast flushes debris and dislodges mucus when the fallopian tubes are undamaged. This does not explain why water does not exhibit similarly impressive effects.The transport of the ovum (or oocyte) from the ovary to the womb is essentially a tribological process. Poppy seed oil is composed, amongst other things of fatty acids and esters both of which are very good at improving the frictional response, or lubricity, of a given system. Good lubricity may help the oocyte to move more easily through the tube, may the prevent the formation of debris in the tubes, prevent the fallopian tubes from closing and/ or aid sperm mobility. All of these effects can be explained by understanding tribology of the system. This research sets out an ambitious goal of measuring the tribological properties of this Mol's observed phenomenon. At its centre is the use of a novel method to nondestructively measure the frictional properties of an oocyte in transit through a simulated fallopian tube using direct observation, mechanical modelling and a machine-learning algorithm.Infertility is a big problem. 186 million women in the developed world are affected by it, equivalent to one in four adults. By understanding the underlining tribology of HSG therapy and the interaction between specific components within the contrast, the surfaces within the reproductive and the physiological reproductive process, a new tailored and extremely effective approach to the treatment of female infertility could be developed.

输卵管阻塞是女性不孕的常见原因。当寻求治疗时，任何干预的第一阶段都将是寻找管道堵塞。这个过程涉及将染料插入子宫，然后可以使用X射线来筛选输卵管开放的程度。这种医疗技术被称为子宫输卵管造影术。使用的染料或对比剂是罂粟籽油基乳剂或水。最近由阿德莱德大学的本·摩尔教授领导的一项研究表明，接受油基造影剂的妇女的怀孕率和生育率增加了10%。这是一个显著的结果，因为更常见的生育治疗，如宫腔内人工授精，可使妊娠率提高1%或2%。然而，解释生育率如何提高的潜在机制尚不清楚。有人建议，输卵管通畅性测试与油造影剂冲洗碎片和驱逐粘液时，输卵管未受损。这并不能解释为什么水没有表现出同样令人印象深刻的效果。卵子（或卵母细胞）从卵巢到子宫的运输本质上是一个摩擦学过程。罂粟籽油由脂肪酸和酯组成，这两者都非常擅长改善给定系统的摩擦响应或润滑性。良好的润滑性可以帮助卵母细胞更容易地移动通过输卵管，可以防止在输卵管中形成碎片，防止输卵管关闭和/或帮助精子移动。所有这些效应都可以通过理解系统的摩擦学来解释。这项研究提出了一个雄心勃勃的目标，即测量这种摩尔观察到的现象的摩擦学特性。其核心是使用一种新方法，通过直接观察、机械建模和机器学习算法，非破坏性地测量卵母细胞在通过模拟输卵管时的摩擦特性。不孕不育是一个大问题。发达国家有1.86亿妇女受其影响，相当于四分之一的成年人。通过了解HSG疗法的基础摩擦学以及造影剂内特定成分之间的相互作用，生殖和生理生殖过程中的表面，可以开发出一种新的定制和非常有效的治疗女性不孕症的方法。