EPSRC Centre for Doctoral Training in Molecular Sciences for Medicine

分子科学，如化学、生物物理学、分子生物学和蛋白质科学，对医学创新和新药和诊断的发现至关重要。除了对健康和社会做出重要贡献外，这一领域的行业也是经济的重要组成部分，对就业数字做出了巨大贡献，目前在全国创造了近50万个就业机会。为了支持和促进该领域未来的经济增长，CDT将提供一批在这两个方面都接受过培训的研究人员，他们将成为该领域未来的创新者和领导者。所有项目都将基于分子和医学科学，并将专注于尚未满足的医疗需求，如了解疾病生物学，识别新的治疗靶点，以及发现和开发新疗法的新方法。具体问题将由CDT内部的研究人员、行业合作伙伴、利益相关者和CDT学生确定。这项研究将围绕三个主题领域进行：疾病生物学、分子和分析设计以及结构生物学和计算。CDT汇集了在这些领域拥有公认跟踪记录的领先研究人员，他们开创了该领域的最新进展，例如多种批准的癌症治疗方法。他们的共同专长将为学生群体提供监督和指导，这些学生将致力于跨越这些研究主题的项目，并将他们的贡献应用于有问题的医学问题。学生队列方法将允许研究团队在具有共同目标的联合项目上共同工作。项目将由学者、产业界伙伴和学生提出，优先考虑与行业相关的人。跨学科的研究和培训计划将为CDT的毕业生提供前所未有的跨学科知识和技能背景。各学科的研究和培训方案将辅之以企业家精神、负责任的创新和项目管理方面的培训和实践经验。综上所述，这将使CDT的毕业生非常受雇主欢迎，使他们拥有预见和实施未来领域创新所需的技能，并使他们能够成为未来的领导者。一个由董事、联席董事、主题负责人和培训协调员组成的结构严密和经验丰富的管理小组将在业界合作伙伴和学生的全面参与下监督CDT的执行。这将确保提供队列培训方案和联合活动，并对挑选项目和招生过程负责。管理团队在业界和学术界提供该领域的研究和培训以及科学领导力和网络培训协调方面有着良好的记录。CDT将作为纽卡斯尔大学和达勒姆大学之间的一个单独的、完全整合的项目提供，将这两个机构的高度互补的技能和背景结合在一起。CDT的概念和结构是与制药、生物技术和合同研究行业的工业伙伴共同制定的，他们对这一领域对CDT的可取性和培训需求以及研究的主题领域和重点的性质提供了至关重要的指导。EPSRC为CDT提供的资金将得到两所大学的大量捐款和学生资助，以及将提供培训、实物捐助和安置以及额外学生资助的行业合作伙伴的大量捐款。

Molecular sciences, such as chemistry, biophysics, molecular biology and protein science, are vital to innovations in medicine and the discovery of new medicines and diagnostics. As well as making a crucial contribution to health and society, industries in this field provide an essential component to the economy and contribute hugely to employment figures, currently generating nearly 500,000 jobs nationally.To enable and facilitate future economic growth in this area, the CDT will provide a cohort of researchers who have training in both aspects of this interface who will be equipped to become the future innovators and leaders in their field.All projects will be based in both molecular and medical sciences and will focus on unmet medical needs, such as understanding of disease biology, identification of new therapeutic targets, and new approaches to discovery and development of novel therapies. Specific problems will be identified by researchers within the CDT, industrial partners, stakeholders and the CDT students. The research will be structured around three theme areas: Biology of Disease, Molecule and Assay Design and Structural Biology and Computation. The CDT brings together leading researchers with a proven track record across these areas and who have pioneered recent advances in the field, such as multiple approved cancer treatments. Their combined expertise will provide supervision and mentorship to the student cohort who will work on projects that span these research themes and bring their contributions to bear on the medical problems in question. The student cohort approach will allow teams of researchers to work together on joint projects with common goals. Projects will be proposed between academics, industrial partners and students with priority given to those with industrial relevance.The programme of research and training across the disciplines will equip graduates of the CDT with an unprecedented background of knowledge and skills across the disciplines. The programme of research and training across the disciplines will be supplemented by training and hands-on experiences of entrepreneurship, responsible innovation and project management. Taken together this will make graduates of the CDT highly desirable to employers, equip them with the skills they need to envisage and implement future innovations in the area and allow them to become the leaders of tomorrow.A structured and highly experienced management group, consisting of a director, co-directors, theme leads and training coordinators will oversee the execution of the CDT with the full involvement of industry partners and students. This will ensure delivery of the cohort training programme and joint events as well as being accountable for the process of selection of projects and student recruitment. The management team has an established track record of delivery of research and training in the field across industry and academia as well as scientific leadership and network training coordination.The CDT will be delivered as a single, fully integrated programme between Newcastle and Durham Universities, bringing together highly complementary skills and backgrounds from the two institutions. The seamless delivery of the programme across the two institutions is enabled by their unique connectivity with efficient transport links and established regional networks.The concept and structure of the CDT has been developed in conjunction with the industrial partners across the pharmaceutical, biotech and contract research industries, who have given vital steer on the desirability and training need for a CDT in this area as well as to the nature of the theme areas and focus of research. EPSRC funding for the CDT will be supplemented by substantial contributions from both Universities with resources and studentship funding and from industry partners who will provide training, in kind contribution and placements as well as additional studentships.