Complement activation in experimental epilepsy: role of C5a receptors

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400,000 patients in Australia suffer from epilepsy and 45% of them suffer from uncontrolled seizures. Epilepsy often develops after head injury or stroke, but no treatments are available to prevent this process. Inflammatory processes seem to be involved in epilepsy. We will investigate if the inflammatory complement factor C5a plays a role in epilepsy and if we can prevent development of seizures in mice. If successful our data will be a prerequisite for later clinical trials.