Complement activation in experimental epilepsy: role of C5a receptors

澳大利亚有40万癫痫患者，其中45%的患者癫痫发作失控。癫痫通常发生在头部损伤或中风后，但没有可用的治疗方法来防止这一过程。炎症过程似乎与癫痫有关。我们将调查炎性补体因子C5a是否在癫痫中发挥作用，以及我们是否可以防止小鼠癫痫的发展。如果成功，我们的数据将是以后临床试验的先决条件。

400,000 patients in Australia suffer from epilepsy and 45% of them suffer from uncontrolled seizures. Epilepsy often develops after head injury or stroke, but no treatments are available to prevent this process. Inflammatory processes seem to be involved in epilepsy. We will investigate if the inflammatory complement factor C5a plays a role in epilepsy and if we can prevent development of seizures in mice. If successful our data will be a prerequisite for later clinical trials.