AIDS: CHARACTERIZATION OF EARLY DEFECTS

细胞介导的各个方面的纵向、前瞻性研究 免疫将在被认为有感染风险的患者群体中进行 由于以下原因而发生严重机会性感染 (01) 社区获得性细胞免疫缺陷综合症，称为艾滋病。 重点将放在早期的、可预测的缺陷的定义上 可用作诊断的自然或适应性细胞免疫 可以及早识别患者的测试。 目前，没有 可以进行最终测试。 这种缺陷的识别是 有望揭示那些 0I 和某些特定疾病的发病机制 已知肿瘤疾病是这种免疫缺陷的并发症 状态。 艾滋病防治的初步经验表明，早期 异常反映在体外产生异常 α-干扰素（IFN）。 将对这一异常现象进行进一步调查 阐明其机制以及它是否是有用的预后或诊断 指标及其对艾滋病发病机制的重要性 并发症。 细胞其他方面的检测方法的发展 免疫，特别是 T 细胞-T 细胞、T 细胞-单核细胞相互作用，以及 干扰素在这些功能中的作用，可能有助于对艾滋病进行进一步的分析。 诊断分析系统的定义将进一步推动流行病学、 这种疾病的治疗和预防方法。

Longitudinal, prospective study of various aspects of cell-mediated immunity will be carried out in patient groups considered at risk for the development of severe opportunistic infections (01) as the result of a community-acquired cellular immunodeficiency syndrome known as AIDS. Emphasis will be placed on the definition of early, predictive defects in natural or adaptive cellular immunity that could be employed as diagnostic tests that permit early identification of patients. At present, no definitive test is available. The identification of such a defect would be expected to shed light on the pathogenesis of those 0I and of certain neoplastic diseases known to be complications of this immune deficiency state. Preliminary experience with AIDS indicates that one early abnormality is reflected in abnormal production in vitro of alpha-interferon (IFN). Further investigation of this abnormality will clarify its mechanism and whether it is a useful prognostic or diagnostic indicator, as well as its importance to the pathogenesis of the AIDS complications. The development of assays of other aspects of cellular immunity, particularly of T cell-T cell, T cell-monocyte interactions, and the role of IFNs in these functions, may permit further analysis of AIDS. The definition of diagnostic assay systems will further epidemiologic, therapeutic and preventive approaches to this disorder.