CLINICAL CENTER FOR TRIALS OF HYPERTENSION PREVENTION

高血压预防试验临床中心

• 批准号: 3552865
• 负责人: NEMAT O. BORHANI
• 金额: $ 40.53万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-09-30 至 1990-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3552865
• 关键词: behavioral medicine; cardiovascular disorder prevention; dietary potassium; dietary supplements; exercise; human subject; human therapy evaluation; hypertension; low salt diet; nutrition education; nutrition related tag; reducing diet; therapy compliance; weight control; young adult human (21-34)

Hypertension is a major risk factor for mortality and morbidity in the USA and most of the Western societies. Drug treatment of hypertension, although effective in reducing mortality and morbidity, is associated with untoward side effects. Because of the magnitude of the problem of hypertension and the inherent fallacy in a policy of using drugs to control hypertension, it seems prudent to test the feasibility, safety, and efficacy of nonpharmacologic methods of intervention (including changes in dietary habits and other relevant life style behaviors) in our approach to primary prevention of hypertension. We have attempted to document our capacity of recruiting 200 (or even 250) eligible participants aged 25-49 years for Phase IB of TOHP and have presented methods of intervention we would like to test. These methods include weight reduction, sodium restriction with potassium supplementation, and physical exercise training. Participants will be assigned randomly to each of these three groups and to a control group. Results in each group of approximately 50 participants will be compared with a control group of approximately 50 participants (a total of 200). In addition, we have discussed our competence and willingness to conduct other intervention procedures such as the biofeedback/relaxation or dietary changes dealing with fat intake or other nutrients such as calcium and magnesium. The intervention method for dietary modification modality will include a combination of group sessions and individual counseling. The adherence to the regimen will be monitored by overnight urinary excretion of Na+ and K+ and by review of 24-hour food record. In exercise training group, participants will be trained for a 20 week period for aerobic dynamic exercise program employing simple modalities of exercise to improve heart rate (HR) and blood pressure (BP).

高血压是美国死亡率和发病率的主要危险因素 以及大多数西方社会。高血压的药物治疗， 虽然在减少死亡率和发病率方面有效，但与 不好的副作用。因为这个问题的严重性 高血压与用药控制政策的内在谬误 高血压，这似乎是谨慎的测试可行性，安全性和 非药物干预方法的有效性(包括 饮食习惯和其他相关的生活方式行为) 高血压的一级预防。 我们试图记录我们招聘200人(甚至250人)的能力。 25-49岁参加TOHP IB阶段的合格参与者 提出了我们想要测试的干预方法。这些方法 包括减肥，用钾限制钠 补充剂和体育锻炼。参与者将是 随机分配到这三组中的每一组和一个对照组。 每组约50名参与者的结果将进行比较 对照组约50人(总计200人)。在……里面 此外，我们已经讨论了我们的能力和愿意进行其他 干预程序，如生物反馈/放松或饮食 改变脂肪摄入量或其他营养素，如钙和 镁。饮食改变方式的干预方法将 包括小组会议和个人咨询相结合。这个 坚持治疗方案将通过通宵尿液排泄量进行监测。 Na+和K+的含量，以及24小时食物记录。在运动训练中 小组，参与者将接受为期20周的有氧训练 采用简单锻炼方式的动态锻炼计划以提高 心率(HR)和血压(BP)。