A comprehensive immunoproteomic analysis of the repertoire and dynamics of human antibody responses to malaria

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Malaria infects 10% of humanity and kills more than two million children annually. We have developed a powerful new approach to comprehensively profile antibody responses against the malaria parasite in PNG children during the critical period of development of disease immunity. The proposed work will help us to better understand the targets and mechanisms of naturally acquired immunity and prioritise the development of future thereapeutic vaccines, drugs or diagnostics.