CLINICAL CENTER FOR TRIALS OF HYPERTENSION PREVENTION

这一提议旨在检验这样一种假设： 增加钾的摄入量，同时减少 钠的摄入和/或钙的补充将防止 预期与年龄相关的血压升高，从而 预防高血压的发展。在众多人中 已提出的非药物干预措施如下 预防高血压的策略大多数现有的 有证据表明我们的营养方法是最有可能的 才能产生显著的效果。作为协作计划的一部分 研究非药物干预的方法，我们 建议招收约200名年龄在25-49岁之间的受试者参加 将检验前述试验的随机平行试验 假设。这项研究将采用析因设计， 结果四组被分配到以下治疗 养生法： (1)低钠(低于70meq/天)，高钾(大于70meq/天) 超过100mEq/天)摄入量 (2)补钙1500毫克/天 (3)第(1)和(2)项方法的结合 (4)补充安慰剂，但不改变饮食 将用于饮食修改的策略将基于， 主要是在停止摄入等卡路里的面包和谷类食品时 替代土豆、大米和/或其他蔬菜资源 复杂的碳水化合物。初步研究表明，这 将容易地实现我们的目标钠(低于70meq/天)和 摩尔钾(大于100mEq/天)的摄入量水平 钠钾比小于1。 一个积极的结果，中断了预期的年龄增长 相关的血压将为大多数 重要的高血压防治群治策略。

This proposal is designed to test the hypothesis that an increased intake of potassium coupled with a reduction in sodium intake, and/or calcium supplementation will prevent the expected age related increase in blood pressure and thereby forestall the development of hypertension. Of the many non-pharmacological interventions that have been proposed as strategies for hypertension prevention the majority of existing evidence favors our nutritional approach as the one most likely to yield significant results. As part of a collaborative approach to the study of non-pharmacologic interventions, we propose to enroll approximately 200 subjects, aged 25-49 in a randomized parallel trial which will test the previously stated hypothesis. The study will have a factorial design that results in the four groups assigned to the following treatment regimens: (1) Low sodium (less than 70 mEQ/day), high potassium (greater than 100 mEq/day) intake (2) Calcium supplementation with 1500 mg elemental calcium/day (3) Combination of the approaches in (1) and (2) (4) Placebo supplementation but no dietary modification The strategy to be used for dietary modification will be based, primarily, upon withdrawal of bread and cereals with isocaloric substitution of potatoes, rice and/or other vegetable sources of complex carbohydrates. Preliminary studies show that this will readily achieve our goal sodium (less than 70 mEQ/day) and potassium (greater than 100 mEq/day) intake levels with a molar sodium/potassium ration less than 1. A positive result that interrupts the expected increase in age related blood pressure would provide the basis for a most important hypertension prevention mass treatment strategy.