Computational modelling to understand early-stage neurodegeneration

了解早期神经退行性疾病的计算模型

• 批准号: nhmrc : 1194910
• 金额: $ 64.52万
• 依托单位国家: 澳大利亚
• 项目类别: Investigator Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://researchdata.edu.au/computational-modelling-understand-stage-neurodegeneration/1778907
• 关键词: Computational; modelling; understand; early; stage

Rather than attempting to reverse neurodegeneration, therapeutic strategies must target the earliest possible stages of disease, when treatments have the potential to prevent or slow down pathological progression. The proposed project will employ computational modelling using functional MRI to deliver highly efficient and sensitive markers of Familial Alzheimer’s disease and Huntington’s disease progression to inform when in the progression of disease clinical trials should take place.

治疗策略必须针对疾病的最早可能阶段，而不是试图逆转神经变性，此时治疗有可能预防或减缓病理进展。拟议的项目将采用计算建模，使用功能性MRI提供家族性阿尔茨海默病和亨廷顿病进展的高效和敏感的标志物，以告知疾病进展时应进行临床试验。