EPSRC Capital Award for Core Equipment: Transformative Upgrade of NMR Facilities

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The main objective of this proposal is to dramatically enhance the capabilities and throughput of the NMR facilities within the School of Physical Sciences/University of Liverpool that underpins our world leading research activities within the remit of EPSRC, including those in the field of Design of New Materials, Energy and Catalysis, as well as in a number of Healthcare chemistry projects. Upon this transformative upgrade, Materials research in the UoL will benefit in several ways from the increased sensitivity provided by the liquid nitrogen cooled, broadband Prodigy CryoProbe that will allow high quality spectra of the insensitive nuclei required for the characterization of precursors and functional molecules and spectra of poorly soluble materials to be obtained. High throughput materials discovery requires rapid, high throughput analysis of products which will be enabled by the improved turnaround times and efficiency afforded by the SampleCase Plus automation system. In the field of Energy and Catalysis, much of this research requires NMR studies of only moderately sensitive or insensitive heteronuclei and variable temperature capabilities which will be enabled by the liquid nitrogen cooled broadband Prodigy CryoProbe. UoL research in Biotechnology and Healthcare rely strongly on multidimensional highly resolved NMR experiments of compounds available only in small amount, i.e. in detection of unstable reaction intermediates and metabolites, and these experiments, that are extremely time-consuming or impractical on our ambient temperature probes, will be enabled by the broadband Prodigy CryoProbe upon this transformative upgrade.