CHEMICAL PROSPECTING IN A COSTA RICAN CONSERVATION AREA

本申请描述了一个国际合作生物多样性组织 (ICBG)以获得的天然产物为基础的药物发现 通过瓜纳卡斯特的国家生物多样性研究所(INBO) 哥斯达黎加的保护区。一个特别的目标是引入热带 昆虫和相关节肢动物进入药物搜索和 发展。虽然众所周知，昆虫利用各种各样的 次生代谢物作为防御剂、毒液和信息素，它们 与植物、微生物或海洋相比，受到的关注要少得多 作为有用药剂的潜在来源的生物体。《无神论》 助理计划将协调生物材料的收集， 将创建一个由国内科学家和辅助专业人员组成的小组来 进行收集(以及追求生态化和系统化 研究)，将从生物材料中提取，并将携带 制定了一项抗疟疾筛查计划。INBIO的活动还将 为国家生物多样性名录做出贡献，并建立系统 生物多样性信息管理和分发。康奈尔大学 助理计划将协调ICBG的活动。它还将 追求精选天然产物的化学表征和合成 在生态的基础上显得特别有趣的产品 领导并将培训哥斯达黎加的化学研究人员 表征、生物测定的发展、基础领域和实验室 与“化学找矿”相关的学科。第三个副手 计划，将由药物研究和开发部门执行 百时美施贵宝的部门，将获得大部分提取物 在INBIO准备，并将在广泛的 生物活性，包括寻找抗癌，抗感染， 心血管、中枢神经系统和皮肤科活动。百时美施贵宝 具有悠久的药物开发历史，并拥有完善的现代化体系 屏幕和预测模型。

This application describes an International Cooperative Biodiversity Group (ICBG) directed toward drug discovery based on natural products obtained via the Instituto Nacional de Biodiversidad (INBio) from the Guanacaste Conservation Area in Costa Rica. One specific aim is to introduce tropical insects and related arthropods into the process of drug search and development. While insects are well known to utilize a wide variety of secondary metabolites as defensive agents, venoms, and pheromones, they have received much less attention than plants, microbes, or marine organisms as potential sources of useful pharmaceutical agents. The INBio Associate Program will coordinate the collection of biological materials, will create a group of in-country scientists and paraprofessionals to conduct the collecting (as well as to pursue ecological and systematic studies), will prepare extracts from biological materials, and will carry out an anti-malarial screening program. INBio's activities will also contribute to the national biodiversity inventory, and establish a system of biodiversity information management and distribution. The Cornell Associate Program will coordinate the ICBG's activities. It will also pursue the chemical characterization and synthesis of selected natural products which appear especially interesting on the basis of ecological leads, and will train Costa Rican researchers in chemical characterization, bioassay development, and basic field and laboratory disciplines related to "chemical prospecting". The third Associate Program, to be carried out by the Pharmaceutical Research and Development Division of Bristol-Myers Squibb, will receive the bulk of the extracts prepared at INBio, and will carry out screening over a broad range of biological activities, including a search for anticancer, anti-infective, cardiovascular, CNS, and dermatological activities. Bristol-Myers Squibb has a long history of drug developing, and has a thoroughly modern system of screens and predictive models.