BARBADOS EYE STUDY

巴巴多斯眼睛研究

• 批准号: 3559609
• 负责人: MCRISTINA LESKE
• 金额: $ 56.47万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 1993-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3559609
• 关键词: South America; blood pressure; body weight; cataract; diabetic cataract; diabetic retinopathy; epidemiology; eye disorder diagnosis; eye refraction disorder; family; fundus oculi; glaucoma; glaucoma test; health surveys; human age group; human subject; intraocular fluid; intraocular pressure; photography; public health; retina degeneration; visual fields

Open-angle glaucoma is a major cause of visual impairment in Black populations. Clinical experience suggests an unusually high glaucoma risk in Barbados, W.I., where most citizens are of African descent. The disease is the major cause of blindness, presenting early and with advanced visual loss. An epidemiologic study is proposed with the major goals of a) measuring the prevalence of glaucoma and its associated impairment, b) evaluating its risk factors, and c) obtaining data to develop interventions to prevent or control visual loss. The proposed research would be the first comprehensive glaucoma study to cover an entire country. Because the disease is a major problem in Black populations, the aims of the proposed study are of widespread public health significance. The secondary goals of the study are to measure prevalence and evaluate risk factors for age-related cataract, macular degeneration, and diabetic retinopathy. Population based epidemiologic data on these diseases are limited or non-existent for Black populations; the proposed study would provide such information at limited additional cost. The above goals would be attained by examining a random sample of 4000 persons 40-84 years in a Ministry of Health polyclinic. Participants would have measurements of intraocular pressure, visual fields, visual acuity, refraction, height, weight, and blood pressure, as well as fundus photographs and an interview on medical, family, and other risk factor history. Blood testing would be performed on cases and a sample of noncases. To assess the feasibility of this project and test the proposed methods of recruitment and data collection, a pilot study was undertaken. Population participation in the pilot study, which examined about 200 randomly selected persons, was 95%. In Black persons >54 years, the prevalence of glaucoma with optic nerve damage was 13%. These results confirm the severity of the glaucoma problem and the need for the proposed study. Because its results would be applicable to other Black populations, the study has the potential to make an important contribution toward blindness prevention in other parts of the world. To further enhance the value of the data obtained, the study plans include a re- examination of the cohort to obtain five-year incidence and natural history data.

开角型青光眼是黑人视力受损的主要原因 人口。临床经验表明有一种异常高的 西德克萨斯州巴巴多斯的青光眼风险，那里的大多数公民都是非洲人 下降。这种疾病是导致失明的主要原因，表现为 早期并伴有严重的视力丧失。一项流行病学研究是 提出的主要目标是：a)衡量 青光眼及其相关损害，b)评估其风险 因素，以及c)获取数据以制定预防措施 或控制视力丧失。这项拟议的研究将是第一次 覆盖整个国家的全面青光眼研究。因为 这种疾病是黑人人口中的一个主要问题，其目标是 这项拟议的研究具有广泛的公共卫生意义。 这项研究的次要目标是衡量流行率和 评估老年性白内障、黄斑的危险因素 变性和糖尿病视网膜病变。基于人口的 关于这些疾病的流行病学数据有限或根本不存在 对于黑人人口；拟议的研究将提供这样的 以有限的额外成本提供信息。 上述目标将通过随机抽取以下样本来实现 4 000名40-84岁的人在卫生部综合诊所就诊。 参与者将测量眼压， 视野、视力、屈光度、身高、体重和血液 压力，以及眼底照片和采访 病史、家族史和其他危险因素史。验血 将在病例和非病例样本上执行。 评估该项目的可行性，并测试建议的 关于征聘和数据收集的方法，开展了一项试点研究 承担了。人口参与试点研究，其中 对200名随机抽取的人进行了调查，结果为95%。穿着黑衣 54岁人群视神经青光眼患病率 损失率为13%。这些结果证实了青光眼的严重性 问题和进行拟议研究的必要性。因为它的结果是 也适用于其他黑人群体，这项研究已经 有可能对失明做出重要贡献 世界其他地区的预防。为进一步加强 所获得的数据的价值，研究计划包括重新 队列检查得出五年发病率和自然发病率 历史数据。