课题基金 / 基金详情

HEPATITIS A VIRUS

HEPATITIS A VIRUS
甲型肝炎病毒
批准号：
3814256
负责人：
S M FEINSTONE
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3814256
关键词：
Hepatovirus antibody neutralization test antiviral antibody bacteriophage lambda complementary DNA conformation epitope mapping genetic library genetic manipulation hepatitis A hepatitis vaccine immunological substance molecular cloning monoclonal antibody tissue /cell culture transposon /insertion element virus DNA virus envelope virus genetics virus protein

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中文摘要
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英文摘要
We have produced HAV "epitope libraries" in the expression vector lambda gt 11. A fragment of HAV cDNA representing the entire capsid coding region was isolated. Random fragments of this DNA were produced by limited DNase digestion and these fragments were cloned into lambda gt 11. These libraries were screened by neutralizing monoclonal antibodies, but specific clones were not identified. However, anti-peptide antibodies representing regions from all four capsid proteins readily identified clones. These results suggest that the epitopes recognized by these antibodies are discontinuous or conformational and a different approach will be required to identify them. A larger battery of monoclonal antibodies is now being used to screen the libraries.
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会议论文
HYBRIDOMA ANTIBODIES TO PATHOGENIC VIRUSES
HEPATITIS C VIRUS NEUTRALIZATION METHOD DEVELOPMENT
  • 批准号：
    6101194
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    --
  • 负责人：
    S M FEINSTONE
  • 依托单位：
    --
STRUCTURAL AND ANTIGENIC ANALYSIS OF HEPATITIS A VIRUS
ANTIGENIC STRUCTURE OF HEPATITIS A VIRUS
  • 批准号：
    3811272
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    --
  • 负责人：
    S M FEINSTONE
  • 依托单位：
    --