EVENT RECORDINGS OF HIGH RISK INFANTS ON APNEA MONITORS

本提案旨在作为多中心协作研究的一部分 呼吸暂停监测仪上高危婴儿的事件记录。 病人， 人员和设施。 这表明， Kapiolani妇女和儿童医疗中心作为场地的适宜性 for this study研究. 该提案将确定（a）频率， 持续时间和基于“真实”的心肺变化（CRA）类型 婴儿呼吸暂停中的“事件”监测器警报;（B）顺应性，以及（c） 记录报警事件的生理和临床意义。 的 Aequitron 9600和兼容设备将用于家庭 监测. 拟议的研究将评估探索性假设， 适当的统计模型和显著性检验， (1)围生期不良事件对CRA的影响（2）CRA与 中枢和自主神经系统的成熟水平，（3） 增强合规性对家庭事件监控的影响，（4）家庭 监测不同种族/民族群体的遵守情况，以及（5） 婴儿呼吸暂停对神经行为发育影响 研究 患者将是白人，夏威夷和菲律宾的婴儿诊断 患有早产儿呼吸暂停并接受柠檬酸咖啡因治疗的婴儿， 与ALTE和SIDS受害者的兄弟姐妹一起。 进入后，婴儿将 分配到家庭呼吸暂停监测计划，并在呼吸暂停后出院。 解决了 除了“真实报警”记录外， 假设将基于多导睡眠图，迷走神经张力测量， 声哭分析。 该研究计划涉及一个试点年的基础上约60 婴儿和预计随访年数以及与以下方面相关的详细信息 扩张.修改须经协作和合作 协定

This proposal is designed as part of a multi-center collaborative study on event recordings of high risk infants on apnea monitors. Patients, personnel and facilities are described. These demonstrate the suitability of Kapiolani Medical Center for Women and Children as a site for this study. This proposal will determine the (a) frequency, duration, and type of cardiorespiratory alterations (CRA) based on "true event" monitor alarms in infantile apnea; (b) compliance, and (c) the physiologic and clinical significance of recorded alarm events. The Aequitron 9600 and compatible equipment will be used for home monitoring. The proposed study will evaluate exploratory hypotheses, with appropriate statistical models and tests of significance related to the (1) effect of adverse perinatal events on CRA (2) relation of CRA to the maturational level of the central and autonomic nervous system, (3) effect of enhanced compliance on home event monitoring, (4) home monitoring compliance in different racial/ethnic groups, and (5) the impact of infantile apnea on neurobehavioral development. Study patients will be Caucasian, Hawaiian, and Filipino infants diagnosed with apnea of prematurity and treated with caffeine citrate, infants with ALTE and siblings of SIDS victims. After entry, infants will be assigned to a Home Apnea Monitor Plan, and discharged after apnea is resolved. In addition to "true alarm" recordings, data for the hypotheses will be based on polysomnograms, vagal tone measures, and acoustic cry analyses. The research plan involves a pilot year based on approximately 60 infants and projected follow-up years as well as details related to expansion. Modifications are subject to collaborative and cooperative agreements.