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IN VIVO NMR STUDIES OF AGING IN CELLS AND ANIMALS

细胞和动物衰老的体内核磁共振研究

批准号：

3808868

负责人：

GL EICHHORN

金额：

$0.0万

依托单位：

NATIONAL INSTITUTE ON AGING

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3808868

关键词：

Alzheimer's disease acid base balance aging arecoline brain disorder chemotherapy brain metabolism cell age cerebrospinal fluid cognition disorders creatine phosphate dopamine drug metabolism exercise haloperidol human subject muscle contraction muscle metabolism neurochemistry neuropharmacology neurotransmitter metabolism nuclear magnetic resonance spectroscopy personal computers pharmacokinetics pharmacology phosphates psychomotor function psychopharmacology pteridines

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英文摘要

NMR Spectroscopy is used to study the metabolic changes associated with exercise in the flexor muscle of the forearm of human volunteers. Isometric exercise at variable workloads as well as constant workload are carried out using a hand dynamometer which is interfaced to a personal computer and a display unit. Changes in phosphocreatine (PCr) and inorganic phosphate (Pi) as well as intracellular pH are monitored via (31)P NMR spectroscopy during the exercise. Age-related differences in these parameters during exercise are studied in subjects of the BLSA using these protocols.

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