FLUDARABINE AND DEOXYCOFORMYCIN IN CHRONIC LYMPHOCYTIC LEUKEMIA

氟达拉滨和脱氧福霉素治疗慢性淋巴细胞白血病

• 批准号: 3882753
• 负责人: MICHAEL R. GREVER
• 金额: --
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3882753
• 关键词: antileukemic agent; antineoplastic antibiotics; chronic leukemia; combination chemotherapy; deoxycoformycin; drug adverse effect; drug metabolism; human subject; human therapy evaluation; lymphocytic leukemia; neoplasm /cancer pharmacology

This is a phase I evaluation of combined therapy with fludarabine monophosphate and deoxycoformycin in patients with chronic lymphocytic leukemia to (1) determine maximum tolerable dose; (2) define qualitative and quantitative toxicities; (3) determine clinical response; and (4) examine pharmacokinetic profiles.

这是与氟达拉滨联合治疗的一期评估