PLANNING GRANT--DIABETES/NEPHROPATHY IN APACHE INDIANS

规划拨款——阿帕奇印第安人的糖尿病/肾病

• 批准号: 3443739
• 负责人: W G WALKER
• 金额: $ 3.15万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-06 至 1993-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3443739
• 关键词: Native Americans; body physical activity; diabetes mellitus; diabetes mellitus genetics; diabetic nephropathy; diet; disease /disorder proneness /risk; glucose tolerance test; health care service planning; human age group; hypertension; insulin sensitivity /resistance; obesity

This application i in response to RFA 91-DK-01 and represents a proposal for support of the planning necessary to develop a grant application to study prevalence, complication rate and risk factors associated with diabetes mellitus in American Indians. The planning effort for which support is requested will be focused upon a study of the White Mountain Apache reservation. There is also available in this area a Hopi Tribe that could be used to provide comparable data and permit comparison of two different native American groups. The primary focus, however, will be directed toward the White Mountain Apache group since these individuals have been studied in the past and there is a uniquely relevant feature of this group related to their nutritional status which makes the assessment of diabetes mellitus in this Apache group of particular importance. In contrast to other groups such as the Pima who have been well-studied and who have a very high incidence of excess obesity as well as diabetes, two relatively recent assessments of the nutritional status of school children of this White Mountain Apache group failed to identify the prevalence of obesity that has been documented for the Pima and for other Navajo. Comparison of data from the White Mountain Apache Indians with data from other Native American populations should aid development of information that is of importance in deciding whether the excess obesity is the most important risk factor associated with non-insulin dependent diabetes mellitus. The grant planning process will include careful attention to appropriate population sampling as well as to the identification of the most accurate approach to characterization of the prevalence of diabetes mellitus as a function of age and nutritional status. Furthermore, any successful planning must involve close consultation and collaboration with the leaders of the White Mountain Apache community as well as the Indian Health Service to ensure optimal cooperation of the Apache community is obtained before any research project is initiated. In addition assessment of the complications including hypertension and renal involvement will be addressed.

本申请是对RFA 91-DK-01的回应，代表一项提案 支持必要的规划，以制定赠款申请， 研究患病率、并发症发生率和与 美国印第安人的糖尿病 计划工作， 所要求的支持将集中在对白色山的研究上 阿帕奇保留区。 在这个地区也有霍皮部落， 可用于提供可比较的数据，并允许比较两个 不同的美洲原住民群体 然而，主要重点将是 直接指向白色山阿帕契部落，因为这些人 在过去已经研究过，有一个独特的相关特征， 这一群体与他们的营养状况有关， 糖尿病的发病率尤为重要。 在 与其他群体形成对比，如皮马人，他们已经得到了很好的研究， 肥胖和糖尿病的发病率很高， 最近对在校儿童营养状况的评估 这个白色山阿帕奇群体的研究未能确定 皮马人和其他纳瓦霍人的肥胖症。 白色山地阿帕奇印第安人的数据与 其他美洲原住民应该帮助信息的发展， 这在决定过度肥胖是否是最重要的 与非胰岛素依赖型糖尿病相关重要危险因素 糖尿病。 赠款规划过程将包括仔细注意 适当的人口抽样以及确定 糖尿病患病率最准确的表征方法 糖尿病是年龄和营养状况的函数。 此外，任何 成功的规划必须与下列各方密切协商和合作： 白色山阿帕奇部落的领导人以及印第安人 健康服务，以确保Apache社区的最佳合作， 在任何研究项目开始之前获得。 此外，评估 的并发症，包括高血压和肾脏受累， 处理。