SYNTHESIS OF RADIOSENSITIZING AGENTS

放射增敏剂的合成

• 批准号: 3614811
• 负责人: LEE W WILLIAM
• 金额: $ 20.21万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-06-01 至 1990-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3614811
• 关键词: cytotoxicity; drug design /synthesis /production; human tissue; nitrogenous heterocyclic compound; radiation dosage; radiosensitizer; tissue /cell culture

The objectives of this contract are to design, synthesize and characterize new and/or novel non-nitro radiosensitizers. The contractor is expected to develop the leads which result from the screening effort (NCI contract N01-CM-67868), which evaluates compounds for their radiosensitivity activity. The contractor is expected to synthesize analogs of the lead compounds and develop in vitro and in vivo data on the efficacy of these compounds as radiosensitizers. New radiosensitizers for clinical use are expected from this contract.

该合同的目标是设计、合成和表征 新的和/或新颖的非硝基放射增敏剂。 承包商预计 开发筛选工作产生的线索（NCI 合同 N01-CM-67868），评估化合物的放射敏感性 活动。 承包商预计将合成铅的类似物 化合物并开发有关这些功效的体外和体内数据 作为放射增敏剂的化合物。 临床使用的新型放射增敏剂是 这份合同的预期。