SYNTHESIS OF DERIVATIVES OF POLYNUCLEAR AROMATIC HYDRO

多核芳烃衍生物的合成

• 批准号: 3632092
• 负责人: JAMES C WILEY
• 金额: $ 46.84万
• 依托单位: CHEMSYN SCIENCE LABORATORIES
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-06-18 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3632092
• 关键词: affinity chromatography; carbopolycyclic compound; chemical carcinogen; chemical synthesis; immunologic techniques; mass spectrometry; nuclear magnetic resonance spectroscopy; thin layer chromatography; ultraviolet spectrometry

The goal of this project is the synthesis, purification and characterization of selected derivatives (primarily oxygenated derivatives) of polynuclear aromatic hydrocarbons in gram quantities. The types of compounds include dihydrodiols; phenols; quinones; diolepoxides; epoxides; dialdehydes resulting from cleavage of cicinally-dissubstituted oxygenated derivatives; alkyl and hydroxyalkyl-substituted parent hydrocarbons; conjugated derivatives (chemical or biosynthetic) such as gluthathiones, glucuronides, and sulfates; and labeled (3H, 13C, 14C) analogs. The compounds are required in carcinogenesis research as authentic standards and substrates to aid in the elucidation of the pathways or carcinogen metabolism, activation, and molecular mechanism of action.

该项目的目标是合成、提纯和 选定的衍生物(主要是含氧衍生物)的表征 以克为单位的多环芳香烃。这些类型的 化合物包括二氢二酚；苯酚；苯二酚；二醇环氧化物；环氧化物； 环状二取代氧的裂解生成的二醛 烷基和羟烷基取代的母体烃； 共轭衍生物(化学或生物合成的)，如谷胱甘肽， 葡萄糖醛酸苷和硫酸盐；以及标记的(~3H，13C，14C)类似物。这个 化合物在致癌研究中被要求作为可信的标准 和底物，以帮助阐明途径或致癌物 代谢、激活和分子作用机制。