Contribution of MDSC-derived cysteine cathepsins in breast cancer metastasis to bone

组织蛋白酶是一种被称为蛋白酶的酶，其功能是切割特定的蛋白质，这一过程对许多正常的细胞功能很重要。异常的组织蛋白酶活性可导致许多病理，包括癌症和炎症。我们正在开发称为基于活性的探针的工具，以研究组织蛋白酶在疾病中的功能。具体来说，我们将研究它们在免疫系统细胞内的活性，目的是开发新的治疗方法。

Cathepsins are enzymes called proteases that function to cleave specific proteins, a process that is important for many normal cellular functions. Aberrant cathepsin activity can result in a number of pathologies, including cancer and inflammation. We are developing tools called activity-based probes to study the function of cathepsins in disease. Specifically, we will investigate their activity within cells of the immune system with the goal of developing novel therapeutic approaches.