SYNTHESIS OF DERIVATIVES OF POLYNUCLEAR AROMATIC

多核芳烃衍生物的合成

• 批准号: 3725469
• 负责人: JAMES WILEY
• 金额: $ 55.11万
• 依托单位: CHEMSYN SCIENCE LABORATORIES
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 1996-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3725469
• 关键词: benzanthracenes; benzopyrenes; chemical carcinogen; chemical registry /resource; drug design /synthesis /production; hydrocarbons; radiochemistry; radiotracer

Under the contract the awardee will operate the NCI's Radiolabelled Chemical Carcinogen Reference Standard Repository. This entails purity analysis and distribution of labelled compounds on hand at the repository to researchers requesting their compounds. Other responsibilities are to resynthesize or repurify decomposed compounds not meeting purity standards and replenishing depleted stocks. Methods and synthesis pathways leading to the preparation of compounds not currently in the inventory are also to be explored. Synthesis of very unstable PAH metabolites such as the diolepoxides of various compounds and shipping them to the requestor is also a major requirement. This is due to synthetic expertise among repository staff. Money received in payment for compounds sold by the repository are used to defray NCI's cost in running the repository.

根据合同，获奖者将操作NCI的放射性标记 化学致癌物参比标准品储存库。 这需要纯洁 储存库现有标记化合物的分析和分布 向研究人员索要他们的化合物 其他职责包括 重新合成或重新纯化不符合纯度的分解化合物 标准并补充耗尽的库存。 方法和综合 导致制备化合物的途径目前不在 还将对库存进行探讨。 极不稳定PAH的合成 代谢物，如各种化合物的二醇环氧化物和运输 这也是一个重要的要求。 这是由于 处置库工作人员的综合专门知识。 收到的付款 用于存储库出售的化合物用于支付NCI的成本， 运行仓库。