BIOLOGICAL SPECIMAN REPOSITORY FOR PATIENTS AT HIGH RISK

高危患者生物样本库

• 批准号: 3633058
• 负责人: P THOMAS DR IYPE
• 金额: $ 16.44万
• 依托单位: BIOLOGICAL RESEARCH FACULTY & FACILITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-11-07 至 1991-11-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3633058
• 关键词: cancer risk; cell bank /registry; fibroblasts; human tissue; neoplastic cell culture for noncancer research

The EEB has a requirement for maintaining and further developing of a repository of skin fibroblast cultures on persons at high risk for cancer. This repository will continue to be a source for irreplaceable cell strains for laboratory investigators studying mechanisms of cancer risk. The Contractor shall grow the cell strains in large quantitites, as requested, to provide collaborating investigators with gram quantities of cells for molecular biologic studies. The Contractor shall also develop a repository of epithelioid cell strains on selected study subjects. The Contractor, in addition, shall propagate and develop are a repository of tumor cell lines initiated in other laboratories. In developing these cell lines, the Contractor shall use the most current laboratory techniques for ensuring the highest viability and cell yield from these cultures. The Contractor shall be responsible for the distribution of cell strains to collaborators and requesting scientists as directed by the Project Officer. The Contractor shall not use contract funds for basic research or in the development of new tests. In general, the Contractor shall engage solely in the application of previously-developed techniques that are pertinent to achieving the stated goals for the contract and already in use in their laboratories.

EEB要求维护和进一步开发 皮肤成纤维细胞培养物的储存库， 治疗癌症 此存储库将继续作为 实验室研究人员研究的不可替代的细胞株 癌症风险的机制。 承包商应培养细胞 大量的菌株，根据要求，提供 合作研究人员与克数量的细胞， 分子生物学研究。 承包商还应制定 在选定的研究对象上的上皮样细胞株的储存库。 此外，承包商还应宣传和发展 在其他实验室启动的肿瘤细胞系库。 在开发这些细胞系时，承包商应使用 确保最高可行性的现有实验室技术 和来自这些培养物的细胞产量。 承包商应 负责将细胞株分发给合作者 并在项目官员的指导下要求科学家。 的 承包商不得将合同资金用于基础研究或 开发新的测试。 一般而言，承包商应 只应用以前开发的技术 与实现合同规定的目标有关的 并且已经在他们的实验室中使用。