RODENT FOUNDATION COLONIES

本项目的目的是运营、维护和提供 纯种，确定的微生物群落相关的啮齿动物基础菌落， 为啮齿动物生产的扩大群体提供繁殖者， 中心. 从以下获得的遗传上确定的近交系原种的后代 NIH存储库或其他来源将由Cesarian获得， 隔离器，并与确定的微生物区系相关。这些人的后代 基础库存将用于为扩建提供育种者 以30个繁殖对的比率建立新的啮齿动物生产群体 Fischer 344/N大鼠和45对C57 BL/6 N和C3 H/HeN MTV- 小鼠和适当数量的其他品系的繁殖对每月。 选用Fishcer 344/N大鼠和B6 C3 F1杂交小鼠作为实验动物 化学品毒理学和生物学评价用动物种属 DTRT/NTP下的致癌特性。基因的完整性 Fischer 344/N大鼠和C57 BL/6 N和C3 H/HeN的表观世代 MTV-小鼠产生B6 C3 F1杂交是必不可少的发展 可靠和准确的动物实验研究数据。集中 基础群体将提供更好的控制遗传完整性， 啮齿类动物扩群和生产群的所有饲养员 生产中心。

The purpose of this project is to operate, maintain and provide pedigreed, defined microflora associated rodent foundation colonies for supplying breeders to the expansion colonies of the rodent production centers. Offspring from genetically defined inbred pedigreed stock obtained from NIH Repository or other sources will be Cesarian derived, maintained in isolators and associated with defined microflora. Offspring from these foundation stock will be used to supply breeders to the expansion colonies of new rodent production colonies at a rate of 30 breeding pairs of Fischer 344/N rats and 45 breeding pairs of C57BL/6N and C3H/HeN MTV- mice and appropriate number of breeding pairs of other strains per month. Fishcer 344/N rats and B6C3F1 hybrid mice are the selected experimental animal species for evaluation of chemicals for toxicologic and carcinogenic properties under DTRT/NTP. The genetic integrity of the apparent generations of Fischer 344/N rats and the C57BL/6N and C3H/HeN MTV- mice to produce the B6C3F1 hybrid is essential for developing reliable and accurate research data in animal experiments. Centralized foundation colonies will provide better control on genetic integrity of all the breeders in the expansion and production colonies of rodent production centers.