CHRONIC TOXICITY STUDIES OF SCOPOLAMINE HYDROBROMIDE

这个项目的目标是描述剂量反应的特征 氢溴酸东莨菪碱的相互关系及毒性 大鼠和小鼠2年慢性灌胃给药 学习。动物将在两年内每周接受5天的治疗。 更多的老鼠将被添加到研究中，以评估潜在的 第1、90、180、270、360和720天的神经行为效应。在……里面 此外，一项同时进行的为期两年的小鼠饮食限制研究 65周的血清激素和血液学中期处死 将进行测量。在研究结束时，所有 核心研究动物将被给予大体和微观 组织病理学检查。65周的临时祭品， 包括血液学、组织病理学和血浆东莨菪碱 测量(仅限小鼠)，将在慢性研究中进行。 NTP将使用这些研究的结果来评估 东莨菪碱的毒理学和致癌性 氢溴酸。

The objective of this project is to characterize dose-response relationships and toxicity of scopolamine hydrobromide administered by oral gavage to rats and mice in 2-year chronic studies. Animals will be treated 5 days per week for 2 years. Extra rats will be added to the study to assess potential neurobehavioral effects at 1, 90, 180, 270, 360, and 720 days. In addition, a simultaneous 2-year diet restriction study in mice with a 65-week interim sacrifice for serum hormone and hematology measurements will be performed. At the end of the study, all core study animals will be given gross and microscopic histopathologic evaluations. A 65-week interim sacrifice, including hematology, histopathology, and plasma scopolamine measurements (mice only), will be performed in the chronic study. The results of these studies will be used by NTP to assess the toxicologic and carcinogenic potential of exposure to scopolamine hydrobromide.