CORONARY HEART DISEASE AND STROKE IN PEOPLE AGED 65-84

65-84 岁人群的冠心病和中风

• 批准号: 3647833
• 负责人: DANIEL O'LEARY
• 金额: $ 29.9万
• 依托单位: NEW ENGLAND DEACONESS HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-06-28 至 1994-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3647833
• 关键词: aging; atherosclerosis; cardiovascular disorder epidemiology; coronary disorder; diet; disease /disorder proneness /risk; health care service utilization; human old age (65+); human subject; physical fitness; physiologic stressor; social support network; stroke

The primary purpose of this project is to investigate risk factors for coronary heart disease (CHD) and stroke in the elderly. Risk factors for the development and progression of cardiovascular diseases will be examined in an elderly cohort. Risk factors for development of overt cardiovascular disease in an older population with prevalent atherosclerosis may differ from those related to the development of atherosclerosis in a younger population. In an elderly population with prevalent atherosclerosis it is important to assess the prediction of clinical disease from measures of preclinical disease such as carotid atherosclerosis. The primary objective of the Ultrasound Reading Center is to develop and implement a system to assess atherosclerosis in the carotid arteries using ultrasound. This will involve 1) coordinating development of a protocol for ultrasound examinations at the Field Centers and a method for evaluating extent of carotid atherosclerosis, 2) training ultrasound technicians of each Field Center, 3) interpreting all ultrasound examinations and 4) monitoring the ultrasound examinations at all Field Centers. During the periods of data collection, the Ultrasound Reading Center shall have the responsibility of assessing within and between individual variation among technicians and coders. The contractor shall serve as the Ultrasound Reading Center for this study. Duties of the Ultrasound Reading Center include equipment selection, protocol development, technician training, central reading' and data transmittal and analysis for the ultrasonographic examinations within the elderly study.

本项目的主要目的是调查风险因素 老年人冠心病和中风。 风险 心血管疾病发展和进展的因素 将在老年人队列中检查疾病。 的危险因素 老年人群中显性心血管疾病的发生 与流行的动脉粥样硬化可能不同， 动脉粥样硬化在年轻人群中的发展。 在患有动脉粥样硬化的老年人群中， 重要的是评估临床疾病的预测， 临床前疾病如颈动脉粥样硬化的测量。 超声阅读中心的主要目标是 开发和实施一个系统，以评估动脉粥样硬化， 用超声波检查颈动脉 这将涉及1） 协调制定超声波检查规程 和一种评价颈动脉狭窄程度的方法 动脉粥样硬化，2）培训各领域超声技术人员 中心，3）解释所有超声检查和4） 监测所有外勤中心的超声波检查。 在数据收集期间，超声阅读 中心有责任在 技术人员和程序员之间的个体差异。 承包商应作为超声阅读中心， 本研究 超声阅读中心的职责包括 设备选择，方案制定，技术人员培训， 中央阅读“和数据传输和分析， 老年人研究中的超声检查。